Аннотация:
Treatment of indomethacin with N-bromosuccinimide in AcOH results in bromination in aromatic positions 4 and 6, while the use of tetrachloromethane allows ultimate bromination at the C(2) Me group of the indole moiety to proceed.
Образец цитирования:
A. V. Ivachtchenko, P. M. Yamanushkin, O. D. Mitkin, O. I. Kiselev, “Bromination of indomethacin”, Mendeleev Commun., 20:2 (2010), 111–112
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc3007
https://www.mathnet.ru/rus/mendc/v20/i2/p111
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Dali Luo, Lanlan Ma, Zhixu Zhou, Zhuyan Huang, “Synthesis, single crystal X-ray analysis, and vibrational spectral studies of ethyl 6-bromo-5-((5-bromopyrimidin-2-yl)oxy)-2-((2, 6-dimethylmorpholino)methyl)-1-methyl-1H-indole-3-carboxylate”, Journal of Molecular Structure, 1198 (2019), 126857
Konstantin V. Balakin, Rosanna Filosa, Sergey N. Lavrenov, Arthur S. Mkrtchyan, Maxim B. Nawrozkij, Ivan A. Novakov, “Arbidol: a quarter-century later. Past, present and future of the original Russian antiviral”, Усп. хим., 87:6 (2018), 509–552; Konstantin V. Balakin, Rosanna Filosa, Sergey N. Lavrenov, Arthur S. Mkrtchyan, Maxim B. Nawrozkij, Ivan A. Novakov, “Arbidol: a quarter-century later. Past, present and future of the original Russian antiviral”, Russian Chem. Reviews, 87:6 (2018), 509–552
A. V. Ivashchenko, P. M. Yamanushkin, O. D. Mit'kin, V. M. Kisil', O. M. Korzinov, V. Yu. Vedenskii, I. A. Leneva, E. A. Bulanova, V. V. Bychko, I. M. Okun', “Synthesis and Antiviral Activity of Ethyl 1,2-dimethyl-5-Hydroxy-1H-Indole-3-carboxylates and Their Derivatives”, Pharm Chem J, 47:12 (2014), 636
A. V. Ivashchenko, P. M. Yamanushkin, O. D. Mit'kin, I. A. Leneva, I. T. Fedyakina, “Synthesis and antiviral activity of functionally substituted indole-3-acetic acids”, Pharm Chem J, 45:5 (2011)
Alexandre V. Ivachtchenko, Pavel M. Yamanushkin, Oleg D. Mitkin, Oleg I. Kiselev, “ChemInform Abstract: Bromination of Indomethacin.”, ChemInform, 41:50 (2010)