Abstract:
The present review relates to the synthesis and structure-activity relationship studies of Arbidol and its structural analogues. The latter are roughly divided into several unequal parts: indole- and benzofuran-based compounds, benzimidazole and imidazopyridine bioisosteres, and ring-expanded quinoline derivatives. Much attention is focused on various types of antiviral activity of the above-mentioned Arbidol congeners, as well as of the parent compound itself. Features of Arbidol synthesis and metabolic changes are also discussed.
Bibliography — 166 references.
Citation:
Konstantin V. Balakin, Rosanna Filosa, Sergey N. Lavrenov, Arthur S. Mkrtchyan, Maxim B. Nawrozkij, Ivan A. Novakov, “Arbidol: a quarter-century later. Past, present and future of the original Russian antiviral”, Russian Chem. Reviews, 87:6 (2018), 509–552