Аннотация:
To enhance the lipophilicity of d-3,5,6-trideoxyinositol monophosphate, the IMPase inhibitor, its bridgehead analogues were suggested on the basis of molecular modeling. Adamantane-1,2- and 1,4-diols were converted into their 1-phosphates via the step of benzylic protection of the secondary hydroxy groups; the Baeyer–Villiger oxidation of 1-hydroxyadamantan-2-one occurred to initially cleave C(1)–C(2) bond.
Образец цитирования:
O. N. Zefirova, I. S. Raguzin, V. V. Gogol, E. V. Nurieva, M. S. Belenikin, “Phosphates of bridgehead alcohols as putative inositol monophosphatase inhibitors: molecular design and synthetic approach”, Mendeleev Commun., 21:5 (2011), 242–244
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc2930
https://www.mathnet.ru/rus/mendc/v21/i5/p242
Эта публикация цитируется в следующих 7 статьяx:
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Valery M. Dembitsky, Tatyana A. Gloriozova, Vladimir V. Poroikov, “Pharmacological profile of natural and synthetic compounds with rigid adamantane-based scaffolds as potential agents for the treatment of neurodegenerative diseases”, Biochemical and Biophysical Research Communications, 529:4 (2020), 1225
N. A. Zefirov, E. V. Nurieva, Yu. A. Pikulina, A. V. Ogon´kov, B. Wobith, S. A. Kuznetsov, O. N. Zefirova, “Adamantane acid esters with alkoxyaryl alcohols: Synthesis, antiproliferative activity, and influence on microtubule network of tumor cells”, Russ Chem Bull, 66:8 (2017), 1503
D. V. Shishov, E. V. Nurieva, N. S. Zefirov, A. V. Mamaeva, O. N. Zefirova, “Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues”, Mendeleev Commun., 24:6 (2014), 370–371
O. N. Zefirova, N. S. Zefirov, “Targeted application of bridged fragments in the design of physiologically active compounds”, Russ Chem Bull, 62:2 (2013), 325
O. N. Zefirova, E. D. Plotnikova, E. V. Nurieva, D. I. Peregud, M. V. Onufriev, N. V. Gulyaeva, “Synthesis of 2-thia-4-azabicyclo[3.3.1]non-3-en-3-amine – bridged nitric oxide synthase inhibitor with enhanced lipophilicity”, Mendeleev Commun., 23:2 (2013), 76–77
I. S. Raguzin, V. V. Gogol, E. V. Nurieva, V. N. Nuriev, O. N. Zefirova, “Synthesis and study of the inhibitory activity of adamantylphosphates with respect to Myo-inositolmonophosphatase”, Moscow Univ. Chem. Bull., 67:1 (2012), 30
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