Аннотация:
2-Thia-4-azabicyclo[3.3.1]non-3-en-3-amine was synthesized as a lipophilic analogue of NO-synthase inhibitor 2-amino-5,6-dihydro- 4H-1,3-thiazine and found to be a potent inhibitor of inducible NO-synthase in vitro. The crystal structure of the key intermediate 2-thia-4-azabicyclo[3.3.1]nonane-3-thione (obtained by cyclization of trans-3-bromocyclohexylamine with carbon disulfide) was determined by X-ray analysis.
Образец цитирования:
O. N. Zefirova, E. D. Plotnikova, E. V. Nurieva, D. I. Peregud, M. V. Onufriev, N. V. Gulyaeva, “Synthesis of 2-thia-4-azabicyclo[3.3.1]non-3-en-3-amine – bridged nitric oxide synthase inhibitor with enhanced lipophilicity”, Mendeleev Commun., 23:2 (2013), 76–77
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc2618
https://www.mathnet.ru/rus/mendc/v23/i2/p76
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Kseniya N. Sedenkova, Olga V. Ryzhikova, Svetlana A. Stepanova, Alexei D. Averin, Sergei V. Kositov, Yuri K. Grishin, Igor P. Gloriozov, Elena B. Averina, “Bis(oxiranes) Containing Cyclooctane Core: Synthesis and Reactivity towards NaN3”, Molecules, 27:20 (2022), 6889
Evgeniya V. Nurieva, Alexander A. Alexeev, Olga N. Zefirova, “Cyclic Isothiourea in Drug Design”, Chem Heterocycl Comp, 57:9 (2021), 889
Alexander A. Alexeev, Evgeniya V. Nurieva, Konstantin A. Lyssenko, Yuri K. Grishin, Olga N. Zefirova, “Novel structural type of bridged urea derivatives bearing azatricyclo[4.3.1.03,8]decane moiety”, Struct Chem, 30:2 (2019), 473
A. A. Alexeev, E. V. Nurieva, T. P. Trofimova, E. A. Chesnakova, Yu. K. Grishin, K. A. Lyssenko, M. V. Filimonova, O. N. Zefirova, “Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock”, Mendeleev Commun., 29:1 (2019), 14–16
E. V. Nurieva, T. P. Trofimova, A. A. Alexeev, A. N. Proshin, E. A. Chesnakova, Yu. K. Grishin, K. A. Lyssenko, M. V. Filimonova, S. O. Bachurin, O. N. Zefirova, “Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity”, Mendeleev Commun., 28:4 (2018), 390–392
D. V. Shishov, E. V. Nurieva, N. S. Zefirov, A. V. Mamaeva, O. N. Zefirova, “Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues”, Mendeleev Commun., 24:6 (2014), 370–371
E. D. Plotnikova, E. V. Nurieva, D. I. Peregud, M. V. Onufriev, N. V. Gulyaeva, V. M. Makarchuk, M. V. Filimonova, N. S. Zefirov, O. N. Zefirova, “Molecular modeling, X-ray diffraction analysis, and the study of iNOS inhibitor activity of 3-imino-2,4-diazabicyclo[3.3.1]nonan-1-ol hydrochloride”, Russ J Org Chem, 49:8 (2013), 1108
O. N. Zefirova, N. S. Zefirov, “Targeted application of bridged fragments in the design of physiologically active compounds”, Russ Chem Bull, 62:2 (2013), 325
Olga N. Zefirova, Evgeniya D. Plotnikova, Evgeniya V. Nurieva, Danil I. Peregud, Mikhail V. Onufriev, Natalia V. Gulyaeva, “ChemInform Abstract: Synthesis of 2‐Thia‐4‐azabicyclo[3.3.1]non‐3‐en‐3‐amine — Bridged Nitric Oxide Synthase Inhibitor with Enhanced Lipophilicity.”, ChemInform, 44:31 (2013)
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