Аннотация:
Novel conjugates of purine and 2-aminopurine linked with heterocyclic amines, including chiral derivatives of 3,4-dihydro-2H-[1,4]benzoxazine, 3,4-dihydro-2H-[1,4]benzothiazine and 1,2,3,4-tetrahydroquinoline, by 6-aminohexanoyl fragment at the 6-position of purine moiety were obtained. For this purpose, replacement of the chlorine atom in 2-amino-6-chloropurine or 6-chloropurine by direct nucleophilic substitution reaction with 6-aminohexanamides or the coupling of 6-(purin-6-ylamino)-6-hexanoic acid with nitrogen heterocycles were used.
Образец цитирования:
V. P. Krasnov, D. A. Gruzdev, E. N. Chulakov, A. Yu. Vigorov, V. V. Musiyak, T. V. Matveeva, A. A. Tumashov, G. L. Levit, V. N. Charushin, “Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment”, Mendeleev Commun., 25:6 (2015), 412–414
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc2427
https://www.mathnet.ru/rus/mendc/v25/i6/p412
Эта публикация цитируется в следующих 10 статьяx:
Victor P. Krasnov, Olga A. Vozdvizhenskaya, Maria A. Baryshnikova, Alexandra G. Pershina, Vera V. Musiyak, Tatyana V. Matveeva, Kseniya V. Nevskaya, Olga Y. Brikunova, Dmitry A. Gruzdev, Galina L. Levit, “Synthesis and Cytotoxic Activity of the Derivatives of N-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds”, Molecules, 28:4 (2023), 1853
Victor P. Krasnov, Vera V. Musiyak, Galina L. Levit, Dmitry A. Gruzdev, Valeriya L. Andronova, Georgii A. Galegov, Iana R. Orshanskaya, Ekaterina O. Sinegubova, Vladimir V. Zarubaev, Valery N. Charushin, “Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and Evaluation of Their Antiviral Activity”, Molecules, 27:13 (2022), 4236
Olga А. Vozdvizhenskaya, Valeriya L. Andronova, Georgii А. Galegov, Galina L. Levit, Victor P. Krasnov, Valery N. Charushin, “Synthesis and antiherpetic activity of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine”, Chem Heterocycl Comp, 57:4 (2021), 490
Victor P. Krasnov, Vladimir V. Zarubaev, Dmitry А. Gruzdev, Olga А. Vozdvizhenskaya, Sergey А. Vakarov, Vera V. Musiyak, Evgeny N. Chulakov, Alexandrina S. Volobueva, Ekaterina O. Sinegubova, Marina А. Ezhikova, Mikhail I. Kodess, Galina L. Levit, Valery N. Charushin, “Novel purine conjugates with N-heterocycles: synthesis and anti-influenza activity”, Chem Heterocycl Comp, 57:4 (2021), 498
Victor P. Krasnov, Galina L. Levit, Vera V. Musiyak, Dmitry A. Gruzdev, Valery N. Charushin, “Fragment-based approach to novel bioactive purine derivatives”, Pure and Applied Chemistry, 92:8 (2020), 1277
Barbara Z. Eletskaya, Dmitry A. Gruzdev, Victor P. Krasnov, Galina L. Levit, Maria A. Kostromina, Alexander S. Paramonov, Alexei L. Kayushin, Inessa S. Muzyka, Tatyana I. Muravyova, Roman S. Esipov, Valeria L. Andronova, Georgiy A. Galegov, Valery N. Charushin, Anatoly I. Miroshnikov, Irina D. Konstantinova, “Enzymatic synthesis of novel purine nucleosides bearing a chiral benzoxazine fragment”, Chem Biol Drug Des, 93:4 (2019), 605
Victor P. Krasnov, Vera V. Musiyak, Olga A. Vozdvizhenskaya, Georgiy A. Galegov, Valeria L. Andronova, Dmitry A. Gruzdev, Evgeny N. Chulakov, Alexey Yu. Vigorov, Marina A. Ezhikova, Mikhail I. Kodess, Galina L. Levit, Valery N. Charushin, “N‐[ω‐(Purin‐6‐yl)aminoalkanoyl] Derivatives of Chiral Heterocyclic Amines as Promising Anti‐Herpesvirus Agents”, Eur J Org Chem, 2019:30 (2019), 4811
A. A. Tumashov, D. A. Gruzdev, A. Yu. Vigorov, V. V. Musiyak, E. N. Chulakov, G. L. Levit, V. P. Krasnov, V. N. Charushin, “Analysis of racemic conjugates of purine with heterocyclic amines by chiral high-performance liquid chromatography”, Russ Chem Bull, 67:9 (2018), 1704
D. A. Gruzdev, E. N. Chulakov, G. L. Levit, M. A. Kravchenko, V. P. Krasnov, V. N. Charushin, “Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids”, Mendeleev Commun., 27:6 (2017), 547–549
B. Z. Eletskaya, I. D. Konstantinova, A. S. Paramonov, R. S. Esipov, D. A. Gruzdev, A. Yu. Vigorov, G. L. Levit, A. I. Miroshnikov, V. P. Krasnov, V. N. Charushin, “Chemoenzymatic arabinosylation of 2-aminopurines bearing the chiral fragment of 7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazines”, Mendeleev Commun., 26:1 (2016), 6–8
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