Abstract:
A series of functionalized furoxans was synthesized, and their effect on the platelet aggregation was estimated using a set of inducers. New hybrid structures comprising the furoxan ring and glycolic or acetylsalicylic acid motifs effectively inhibit aggregate formation induced by adenosine diphosphate and adrenaline. Studies of their NO-donor ability showed that their antiplatelet effects were mainly independent of the NO action.
Citation:
A. A. Larin, L. L. Fershtat, N. E. Ustyuzhanina, M. L. Gening, N. E. Nifantiev, N. N. Makhova, “New hybrid furoxan structures with antiaggregant activity”, Mendeleev Commun., 28:6 (2018), 595–597
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This publication is cited in the following 18 articles:
Yuri A Sidunets, Valeriya G Melekhina, Leonid L Fershtat, “Tandem diazotization/cyclization approach for the synthesis of a fused 1,2,3-triazinone-furazan/furoxan heterocyclic system”, Beilstein J. Org. Chem., 20 (2024), 2342
V. N. Charushin, E. V. Verbitskiy, O. N. Chupakhin, D. V. Vorobyeva, P. S. Gribanov, S. N. Osipov, A. V. Ivanov, S. V. Martynovskaya, E. F. Sagitova, V. D. Dyachenko, I. V. Dyachenko, S. G. Krivokolylsko, V. V. Dotsenko, A. V. Aksenov, D. A. Aksenov, N. A. Aksenov, A. A. Larin, L. L. Fershtat, V. M. Muzalevskiy, V. G. Nenajdenko, A. V. Gulevskaya, A. F. Pozharskii, E. A. Filatova, K. V. Belyaeva, B. A. Trofimov, I. A. Balova, N. A. Danilkina, A. I. Govdi, A. S. Tikhomirov, A. E. Shchekotikhin, M. S. Novikov, N. V. Rostovskii, A. F. Khlebnikov, Yu. N. Klimochkin, M. V. Leonova, I. M. Tkachenko, V. A.-o. Mamedov, V. L. Mamedova, N. A. Zhukova, V. E. Semenov, O. G. Sinyashin, O. V. Borshchev, Yu. N. Luponosov, S. A. Ponomarenko, A. S. Fisyuk, A. S. Kostyuchenko, V. G. Ilkin, T. V. Beryozkina, V. A. Bakulev, A. S. Gazizov, A. A. Zagidullin, A. A. Karasik, M. E. Kukushkin, E. K. Beloglazkina, N. E. Golantsov, A. A. Festa, L. G. Voskresenskii, V. S. Moshkin, E. M. Buev, V. Ya. Sosnovskikh, I, “The chemistry of heterocycles in the 21st century”, Russian Chem. Reviews, 93:7 (2024), RCR5125
Irina A. Stebletsova, Alexander A. Larin, Ivan V. Ananyev, Leonid L. Fershtat, “Regioselective Synthesis of NO-Donor (4-Nitro-1,2,3-triazolyl)furoxans via Eliminative Azide–Olefin Cycloaddition”, Molecules, 28:19 (2023), 6969
Nina N. Makhova, Leonid L. Fershtat, Comprehensive Heterocyclic Chemistry IV, 2022, 190
Kseniia Yu Titenkova, Alexander V. Shaferov, Alexander A. Larin, Margarita A. Epishina, Alexander S. Kulikov, Ivan V. Ananyev, Leonid L. Fershtat, “Tandem acid-promoted intramolecular azide-hydrazone electrocyclization/hydrolysis approach for the synthesis of N-Aminotetrazoles”, Tetrahedron, 103 (2022), 132563
D. A. Chaplygin, A. A. Larin, L. L. Fershtat, “Synthesis of N- and S-substituted arylglyoximes via transformations of 4-arylfuroxans”, Russ Chem Bull, 71:8 (2022), 1745
Egor S. Zhilin, Nadezhda E. Ustyuzhanina, Leonid L. Fershtat, Nikolay E. Nifantiev, Nina N. Makhova, “Antiaggregant effects of (1,2,5‐oxadiazolyl)azasydnone ring assemblies as novel antiplatelet agents”, Chem Biol Drug Des, 100:6 (2022), 1017
Margarita A. Epishina, Alexander S. Kulikov, Leonid L. Fershtat, “4-Amino-3-(1-{[amino(3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)methylene]hydrazinylidene}ethyl)-1,2,5-oxadiazole 2-Oxide”, Molbank, 2022:3 (2022), M1425
Leonid L. Fershtat, Egor S. Zhilin, “Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors”, Molecules, 26:18 (2021), 5705
A. S. Kulikov, M. A. Epishina, E. S. Zhilin, A. D. Shuvaev, L. L. Fershtat, N. N. Makhova, “Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors”, Mendeleev Commun., 31:1 (2021), 42–45
Dmitry M. Bystrov, Ivan V. Ananyev, Leonid L. Fershtat, Nina N. Makhova, “Direct Synthesis of N-(1,2,5-Oxadiazolyl)hydrazones through a Diazotization/Reduction/Condensation Cascade”, J. Org. Chem., 85:23 (2020), 15466
Xuanhua Guo, Guangqiang Xu, Li Zhou, Huating Yan, Xin-Qi Hao, Qinggang Wang, “Synthesis and application of α-carbonyl nitrile oxides”, Org. Chem. Front., 7:17 (2020), 2467
Egor S. Zhilin, Michael S. Polkovnichenko, Ivan V. Ananyev, Leonid L. Fershtat, Nina N. Makhova, “Novel Arylazo‐1,2,5‐oxadiazole Photoswitches: Synthesis, Photoisomerization and Nitric Oxide Releasing Properties”, ChemPhotoChem, 4:12 (2020), 5346
N. N. Makhova, L. I. Belen'kii, G. A. Gazieva, I. L. Dalinger, L. S. Konstantinova, V. V. Kuznetsov, A. N. Kravchenko, M. M. Krayushkin, O. A. Rakitin, A. M. Starosotnikov, L. L. Fershtat, S. A. Shevelev, V. Z. Shirinian, V. N. Yarovenko, “Progress in the chemistry of nitrogen-, oxygen- and sulfur-containing heterocyclic systems”, Russian Chem. Reviews, 89:1 (2020), 55–124
S. A. Pukhov, L. A. Anikina, A. A. Larin, L. L. Fershtat, A. S. Kulikov, N. N. Makhova, “Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells”, Russ Chem Bull, 68:1 (2019), 158
Egor S. Zhilin, Dmitry M. Bystrov, Ivan V. Ananyev, Leonid L. Fershtat, Nina N. Makhova, “Straightforward Access to the Nitric Oxide Donor Azasydnone Scaffold by Cascade Reactions of Amines”, Chemistry A European J, 25:63 (2019), 14284
Egor S. Zhilin, Leonid L. Fershtat, Dmitry M. Bystrov, Alexander S. Kulikov, Artem O. Dmitrienko, Ivan V. Ananyev, Nina N. Makhova, “Renaissance of 1,2,5‐Oxadiazolyl Diazonium Salts: Synthesis and Reactivity”, Eur J Org Chem, 2019:26 (2019), 4248
M. A. Epishina, A. S. Kulikov, L. L. Fershtat, I. V. Ananyev, N. N. Makhova, “Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans”, Mendeleev Commun., 29:3 (2019), 288–291
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