Abstract:
The effective synthesis of pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans, comprising furoxan moiety as NO-donor and pharmacophoric pyrazolylthiazole fragment is based on the condensation of (2-hydrazinylthiazol-4-yl)furoxan hydrobromides with linear 1,3-diketones. The reaction proceeds through hydroxypyrazoline intermediate.
Citation:
M. A. Epishina, A. S. Kulikov, L. L. Fershtat, I. V. Ananyev, N. N. Makhova, “Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans”, Mendeleev Commun., 29:3 (2019), 288–291
Linking options:
https://www.mathnet.ru/eng/mendc1498
https://www.mathnet.ru/eng/mendc/v29/i3/p288
This publication is cited in the following 7 articles:
K. A. Kochetkov, O. N. Gorunova, N. A. Bystrova, P. V. Dudina, M. G. Akimov, “Synthesis and physiological activity of new imidazolidin-2-one bis-heterocyclic derivatives”, Russ Chem Bull, 71:11 (2022), 2395
K. A. Kochetkov, O. N. Gorunova, N. A. Bystrova, “5-Hydroxy-1-phenylimidazolidine-2-thione as a new amidoalkylating agent for heterocyclic compounds”, Russ Chem Bull, 71:3 (2022), 587
Hadis Khodadad, Farhad Hatamjafari, Khalil Pourshamsian, Babak Sadeghi, “Microwave-assisted Synthesis of Novel Pyrazole Derivatives and their Biological Evaluation as Anti-Bacterial Agents”, CCHTS, 24:5 (2021), 695
Leonid L. Fershtat, Egor S. Zhilin, “Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors”, Molecules, 26:18 (2021), 5705
A. S. Kulikov, M. A. Epishina, E. S. Zhilin, A. D. Shuvaev, L. L. Fershtat, N. N. Makhova, “Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors”, Mendeleev Commun., 31:1 (2021), 42–45
N. N. Makhova, L. I. Belen'kii, G. A. Gazieva, I. L. Dalinger, L. S. Konstantinova, V. V. Kuznetsov, A. N. Kravchenko, M. M. Krayushkin, O. A. Rakitin, A. M. Starosotnikov, L. L. Fershtat, S. A. Shevelev, V. Z. Shirinian, V. N. Yarovenko, “Progress in the chemistry of nitrogen-, oxygen- and sulfur-containing heterocyclic systems”, Russian Chem. Reviews, 89:1 (2020), 55–124
L. A. Sviridova, P. S. Protopopova, M. G. Akimov, M. S. Dudina, E. K. Melnikova, K. A. Kochetkov, “Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles”, Mendeleev Commun., 30:3 (2020), 347–349
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