Abstract:
Novel bis-quaternary ammonium compounds with a p-terphenyl spacer between two pyridinium heads were synthesized. Hit compound with C8H17 aliphatic substituent is superior to known benzalkonium chloride, miramistin and chlorhexidine bisgluconate in MIC values against five pathogenic bacteria.
Citation:
A. N. Vereshchagin, N. A. Frolov, V. Yu. Konyuhova, E. O. Dorofeeva, K. A. Hansford, M. P. Egorov, “Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer”, Mendeleev Commun., 30:4 (2020), 424–426
Linking options:
https://www.mathnet.ru/eng/mendc1211
https://www.mathnet.ru/eng/mendc/v30/i4/p424
This publication is cited in the following 17 articles:
Nikita A. Frolov, Alexander A. Tyutin, Alexandra N. Tyurina, Mary A. Seferyan, Elena V. Detusheva, Elizabeth Son, Evgeniya A. Saverina, Anatoly N. Vereshchagin, “Expanding the Variety of Pyridinium‐Based Bis‐QACs with Antimicrobial Properties: Investigation into Linker Structure‐Activity Correlation”, ChemMedChem, 2025
Robin Schulte, Dustin Schade, Thomas Paululat, Heiko Ihmels, “Gilding the Lily: Studies on the Effects of Successive Loading of Light Energy‐Storing Molecules with Norbornadiene Units”, Eur J Org Chem, 2024
Günter Kampf, Antiseptic Stewardship, 2024, 407
Günter Kampf, Antiseptic Stewardship, 2024, 653
Michaela Fecková, Martina Vachtlová, Jan Podlesný, Zuzana Burešová, Oldřich Pytela, Milan Klikar, Jiří Janda, Hana Burešová, Radek Pjatkan, Filip Bureš, “Structural tailoring of p-terphenyl scaffold: Towards advanced plastic scintillator”, Dyes and Pigments, 219 (2023), 111593
A. N. Vereshchagin, A. P. Minaeva, ACTUAL PROBLEMS OF ORGANIC CHEMISTRY AND BIOTECHNOLOGY (OCBT2020): Proceedings of the International Scientific Conference, 2390, ACTUAL PROBLEMS OF ORGANIC CHEMISTRY AND BIOTECHNOLOGY (OCBT2020): Proceedings of the International Scientific Conference, 2022, 020086
S. A. Rzhevskiy, M. A. Topchiy, V. N. Bogachev, L. I. Minaeva, I. R. Cherkashchenko, K. V. Lavrov, G. K. Sterligov, M. S. Nechaev, A. F. Asachenko, “Solvent-free palladium-catalyzed C–O cross-coupling of (hetero)aryl halides with primary alcohols”, Mendeleev Commun., 32:2 (2022), 258–259
N. A. Frolov, V. A. Smirnov, E. V. Detusheva, A. N. Vereshchagin, “Novel naphthalene-based bis-pyridinium compounds with pronounced antibacterial activity”, Mendeleev Commun., 32:5 (2022), 606–608
Anatoly N. Vereshchagin, Nikita A. Frolov, Ksenia S. Egorova, Marina M. Seitkalieva, Valentine P. Ananikov, “Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials”, IJMS, 22:13 (2021), 6793
Anatoly N. Vereshchagin, Nikita A. Frolov, Alexandra P. Minaeva, Elena V. Detusheva, Yana V. Derkach, Mikhail P. Egorov, “Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives”, Mendeleev Communications, 31:3 (2021), 368
Nikita A. Frolov, Ksenia A. Fedoseeva, Karl A. Hansford, Anatoly N. Vereshchagin, “Novel Phenyl‐Based Bis‐quaternary Ammonium Compounds as Broad‐Spectrum Biocides”, ChemMedChem, 16:19 (2021), 2954
A. N. Vereshchagin, N. A. Frolov, E. V. Detusheva, MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE, 2388, MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE, 2021, 020038
A. N. Vereshchagin, N. A. Frolov, MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE, 2388, MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE, 2021, 030045
A. N. Vereshchagin, A. P. Minaeva, M. P. Egorov, “Synthesis and antibacterial activity of new tetrakisquaternary ammonium compounds based on pentaerythritol and 3-hydroxypyridine”, Russ Chem Bull, 70:3 (2021), 545
Anatoly N. Vereshchagin, Nikita A. Frolov, Valeria Yu Konyuhova, Ekaterina A. Kapelistaya, Karl A. Hansford, Mikhail P. Egorov, “Investigations into the structure–activity relationship in gemini QACs based on biphenyl and oxydiphenyl linker”, RSC Adv., 11:6 (2021), 3429
A. N. Vereshchagin, N. A. Frolov, E. V. Detusheva, MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE, 2388, MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE, 2021, 030046
A. N. Vereshchagin, N. A. Frolov, A. S. Pakina, K. A. Hansford, M. P. Egorov, “Synthesis and biological evaluation of novel bispyridinium salts containing naphthalene-2,7-diylbis(oxy) spacer”, Mendeleev Commun., 30:6 (2020), 703–705
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