Аннотация:
New nanocomposites based on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane (APS), including those using N-(phosphonomethyl)iminodiacetic acid (PMIDA), were obtained, and the immobilization of the antitumor agent doxorubicin (Dox) on nanocomposites was examined. It has been shown that the binding of Dox to the negatively charged surface of SiO2 particles occurs more efficiently than that to the APS-modified surface with positively charged amino groups; the presence of PMIDA molecules on the surface significantly increased the loading content. Based on DFT calculations, a mechanism for Dox binding to the surface of the synthesized nanocomposites was proposed.
Образец цитирования:
A. M. Demin, A. V. Vakhrushev, M. S. Valova, M. A. Korolyova, M. A. Uimin, A. S. Minin, K. A. Chistyakov, V. P. Krasnov, V. N. Charushin, “Features of doxorubicin adsorption on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane”, Mendeleev Commun., 33:2 (2023), 160–163
V. A. Kurmaz, D. V. Konev, S. V. Kurmaz, N. S. Emel'yanova, “Electrochemical Study of the Antitumor Antibiotic Doxorubicin in Its Free Form and Encapsulated in a Biocompatible Copolymer of N-Vinylpyrrolidone and (di)Methacrylates”, Russ J Electrochem, 60:4 (2024), 321
Zhihui Yang, Xiaochen Wang, Yuanrong Wang, Jinyun Yang, Haifeng Lu, “A novel route for the synthesis of phosphonate-containing siloxanes by the catalyst-free Kabachnik—Fields reaction”, Russ Chem Bull, 73:9 (2024), 2725
V. A. Kurmaz, D. V. Konev, S. V. Kurmaz, N. S. Emelyanova, “Electrochemical study of the free form of anti-tumor antibiotic doxorubicin and encapsulated in a biocompatible copolymer of N-vinyl pyrrolidone with (di)methacrylates”, Èlektrohimiâ, 60:4 (2024), 309
D. V. Pryazhnikov, O. O. Efanova, I. V. Kubrakova, “Formation of a 'protein corona' on the Fe3O4@SiO2 nanoparticles surface”, Mendeleev Commun., 34:3 (2024), 427–429
N. N. Sudareva, I. I. Tarasenko, D. N. Suslov, O. M. Suvorova, K. A. Kolbe, G. Y. Yukina, M. L. Tyndyk, Yu. G. Zmitrichenko, E. G. Korzhikova-Vlakh, “Doxorubicin delivery systems based on polypeptide nanoparticles for subcutaneous administration in cancer therapy”, Mendeleev Commun., 34:1 (2024), 18–21
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