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Эта публикация цитируется в 6 научных статьях (всего в 6 статьях)
The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids
A. Yu. Sukhorukova, S. O. Andryushkevichb, G. G. Chilova, A. A. Zeifmana, I. Svitankoab, S. L. Ioffea
a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
b Higher Chemical College of the Russian Academy of Sciences, D.I. Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
Аннотация:
Diastereoselective synthesis of 4-amino-7-hydroxyheptanoic acids 1, new GABA analogues, was performed involving reduction of C-3 functionalized 5,6-dihydro-4H-1,2-oxazines available from nitroethane. Molecular docking studies showed that amino acids of type 1 may bind to GABA transaminase, however, no inhibition was observed in the experiments with the enzyme.
Образец цитирования:
A. Yu. Sukhorukov, S. O. Andryushkevich, G. G. Chilov, A. A. Zeifman, I. Svitanko, S. L. Ioffe, “The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids”, Mendeleev Commun., 21:4 (2011), 183–185
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc2908 https://www.mathnet.ru/rus/mendc/v21/i4/p183
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