Synthesis of sarcodictyin A analogue containing 14-methyl group and C(12)=C(13) bond in ring A from levoglucosenone

Starting from levoglucosenone piperilene Diels–Alder adduct a total synthesis of sarcodictyin A analogue containing 14-methyl group and C(12)=C(13) bond in ring A was performed, where the key step was the intramolecular cyclization between acetylene and aldehyde moieties to produce a 10-membered carbocycle.