Synthesis of 3-(2,3,5,6-tetrafluoropyridinylthio)pyrazoles from 3-aminopyrazoles

Pyrazoles bearing (2,3,5,6-tetrafluoropyridinyl)thio group were obtained from 3-aminopyrazoles. The reaction is performed by diazotization of starting amines followed by treatment of the intermediate diazonium salts with 2,3,5,6-tetrafluoropyridine-4-thiol and potassium carbonate. The method is best applied towards 4-substituted 3-aminopyrazoles.