Аннотация:
Four new tricyclic derivatives of 3,7-diazabicyclo[3.3.1]-nonane (bispidine) have been synthesized. In vitro patch clamp investigation has revealed for one of them the positive modulation of the kainate-induced AMPA receptor currents in a nanomolar concentration range, and for two other compounds the corresponding negative modulation has been demonstrated.
Образец цитирования:
M. I. Lavrov, P. N. Veremeeva, D. S. Karlov, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “Tricyclic derivatives of bispidine as AMPA receptor allosteric modulators”, Mendeleev Commun., 29:6 (2019), 619–621