New tricyclic cage compound as allosteric modulator of the glutamatergic system: synthesis and biological activity

A new tricyclic derivative of 1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonane was synthesized in three steps using 2-aminoindane-5-carbonitrile. A positive modulatory activity of this compound towards the glutamatergic system in a wide range of nanomolar and subnanomolar concentrations has been demonstrated in electrophysiological studies in vitro using patch clamp technique. A putative binding mode of this compound has been revealed by means of molecular docking and molecular dynamics simulations.