Аннотация:
The title compound has been synthesized and assessed in vitro by means of electrophysiological patch clamp technique revealing a positive modulatory effect on the kainate-induced currents in Purkinje neurons in a wide concentration range from 10–12 to 10–6 m. Molecular docking and molecular dynamics simulation revealed a putative binding mode of this compound in the binding site of positive allosteric modulators of AMPA receptors.
Образец цитирования:
J. Matthews, P. N. Veremeeva, E. A. Golubeva, M. I. Lavrov, E. V. Radchenko, M. A. Topchiy, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “7-Benzyl-1,5-dimethyl-3-piperonyloyl-3,7-diazabicyclo[3.3.1]nonan-9-one as an allosteric modulator of glutamatergic system”, Mendeleev Commun., 34:3 (2024), 354–356
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc127
https://www.mathnet.ru/rus/mendc/v34/i3/p354
Эта публикация цитируется в следующих 1 статьяx:
James Matthews, Polina N. Veremeeva, Elena A. Golubeva, Mstislav I. Lavrov, Eugene V. Radchenko, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Vladimir A. Palyulin, “Synthesis and modulatory activity of 3-acetyl-7-(benzofuran-5-carbonyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one on AMPA receptors”, Chem Heterocycl Comp, 2025
Обратная связь: