Аннотация:
New water soluble conjugates of chlorin e6 derivative–zinc complex with β-d-galactose or β-d-glucose have been synthesized as potential agents for the photodynamic therapy of cancer. They exhibit photoinduced cytotoxicity at low micromolar concentrations with IC50(dark)/IC50(light) ratio of ∼50.
Образец цитирования:
N. S. Kuzmina, V. F. Otvagin, L. V. Krylova, A. V. Nyuchev, Yu. V. Romanenko, O. I. Koifman, I. V. Balalaeva, A. Yu. Fedorov, “Synthesis and antiproliferative activity of new chlorin e6 glycoconjugates”, Mendeleev Commun., 30:2 (2020), 159–161
Vasilii F. Otvagin, Lubov V. Krylova, Nina N. Peskova, Natalia S. Kuzmina, Ekaterina A. Fedotova, Alexander V. Nyuchev, Yuliya V. Romanenko, Oscar I. Koifman, Sergey Z. Vatsadze, Hans-Günther Schmalz, Irina V. Balalaeva, Alexey Yu Fedorov, “A first-in-class β-glucuronidase responsive conjugate for selective dual targeted and photodynamic therapy of bladder cancer”, European Journal of Medicinal Chemistry, 269 (2024), 116283
Natalia S. Kuzmina, Ekaterina A. Fedotova, Petar Jankovic, Galina P. Gribova, Alexander V. Nyuchev, Alexey Yu. Fedorov, Vasilii F. Otvagin, “Enhancing Precision in Photodynamic Therapy: Innovations in Light-Driven and Bioorthogonal Activation”, Pharmaceutics, 16:4 (2024), 479
I. I. Stoikov, I. S. Antipin, V. A. Burilov, A. R. Kurbangalieva, N. V. Rostovskii, A. S. Pankova, I. A. Balova, Yu. O. Remizov, L. M. Pevzner, M. L. Petrov, A. V. Vasilyev, A. D. Averin, I. P. Beletskaya, V. G. Nenajdenko, E. K. Beloglazkina, S. P. Gromov, S. S. Karlov, T. V. Magdesieva, A. A. Prishchenko, S. V. Popkov, A. O. Terent'ev, G. V. Tsaplin, T. P. Kustova, L. B. Kochetova, N. A. Magdalinova, E. A. Krasnokutskaya, A. V. Nyuchev, Yu. L. Kuznetsova, A. Yu. Fedorov, A. Yu. Egorova, V. S. Grinev, V. V. Sorokin, K. L. Ovchinnikov, E. R. Kofanov, A. V. Kolobov, V. L. Rusinov, G. V. Zyryanov, E. V. Nosov, V. A. Bakulev, N. P. Belskaya, T. V. Berezkina, D. L. Obydennov, V. Ya. Sosnovskikh, S. G. Bakhtin, O. V. Baranova, V. S. Doroshkevich, G. Z. Raskildina, R. M. Sultanova, S. S. Zlotskii, V. D. Dyachenko, I. V. Dyachenko, A. S. Fisyuk, V. V. Konshin, V. V. Dotsenko, E. A. Ivleva, A. N. Reznikov, Yu. N. Klimochkin, D. A. Aksenov, N. A. Aksenov, A. V. Aksenov, V. V. Burmistrov,, “Organic Chemistry in Russian Universities. Achievements of Recent Years”, Russ J Org Chem, 60:8 (2024), 1361
I. I. Stoykov, I. S. Antipin, V. A. Burilov, A. R. Kurbangalieva, N. V. Rostovsky, A. S. Pankova, I. A. Balova, Yu. O. Remizov, L. M. Pevzner, M. L. Petrov, A. V. Vasily, A. D. Averin, I. P. Beletskaya, V. G. Nenaydenko, E. K. Beloglazkina, S. P. Gromov, S. S. Karlov, T. V. Magdesieva, A. A. Prishchenko, S. V. Popkov, A. O. Terentyev, G. V. Tsaplin, T. P. Kustova, L. B. Kochetova, N. A. Magdalinova, E. A. Krasnokutskaya, A. V. Nyuchev, Yu. L. Kuznetsova, A. Yu. Fedorov, A. Yu. Egorova, V. S. Grinev, V. V. Sorokin, K. L. Ovchinnikov, E. R. Kofanov, A. V. Kolobov, V. L. Rusinov, G. V. Zyryanov, E. V. Nosov, V. A. Bakulev, N. P. Belskaya, T. V. Berezkina, D. L. Obydennov, V. Ya. Sosnovskikh, S. G. Bakhtin, O. V. Baranova, V. S. Doroshkevich, G. Z. Raskildina, R. M. Sultanova, S. S. Zlotskiy, V. D. Dyachenko, I. V. Dyachenko, A. S. Fisyuk, V. V. Konshin, V. V. Dotsenko, E. A. Ivleva, A. N. Reznikov, Yu. N. Klimochkin, D. A. Aksenov, N. A. Aksenov, A. V. Aksenov, V. V. Burmistrov, G. M. But, “Organic Chemistry in Russian Universities: Achievements of recent years”, Žurnal organičeskoj himii, 60:2-3 (2024)
Natalia S. Kuzmina, Vasilii F. Otvagin, Alexander A. Maleev, Maria A. Urazaeva, Alexander V. Nyuchev, Stanislav K. Ignatov, Andrei E. Gavryushin, Alexey Yu. Fedorov, “Development of novel porphyrin/combretastatin A-4 conjugates for bimodal chemo and photodynamic therapy: Synthesis, photophysical and TDDFT computational studies”, Journal of Photochemistry and Photobiology A: Chemistry, 433 (2022), 114138
O. I. Koifman, T. A. Ageeva, “Main Strategies for the Synthesis of meso-Arylporphyrins”, Russ J Org Chem, 58:4 (2022), 443
N. Sh. Lebedeva, O. I. Koifman, “Supramolecular Systems Based on Macrocyclic Compounds with Proteins: Application Prospects”, Russ J Bioorg Chem, 48:1 (2022), 1
Natalia S. Kuzmina, Vasilii F. Otvagin, Alexander A. Maleev, Alexander V. Nyuchev, Stanislav K. Ignatov, Andrei E. Gavryushin, Alexey Fedorov, “Development of Novel Porphyrin/Combretastatin A-4 Conjugates for Bimodal Chemo and Photodynamic Therapy: Synthesis, Photophysical and Tddft Computational Studies”, SSRN Journal, 2022
Vasilii F. Otvagin, Natalia S. Kuzmina, Ekaterina S. Kudriashova, Alexander V. Nyuchev, Andrei E. Gavryushin, Alexey Yu. Fedorov, “Conjugates of Porphyrinoid-Based Photosensitizers with Cytotoxic Drugs: Current Progress and Future Directions toward Selective Photodynamic Therapy”, J. Med. Chem., 65:3 (2022), 1695
M. V. Mal'shakova, E. E. Rasova, I. O. Velegzhaninov, D. V. Belykh, “Synthesis of novel chlorophyll a derivatives bearing glucose moieties and estimation of their photocytotoxic activity”, Russ Chem Bull, 71:3 (2022), 531
L. A. Tulaeva, E. I. Pushkareva, O. V. Tolstikova, D. V. Belykh, “Exo ring opening in methyl pheophorbide a 132-amide derivatives under the action of amines”, Russ Chem Bull, 70:2 (2021), 359
Javier Hernández-Gil, Jason S. Lewis, Thomas Reiner, Charles Michael Drain, Junior Gonzales, “Leveraging synthetic chlorins for bio-imaging applications”, Chem. Commun., 56:83 (2020), 12608
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