Аннотация:
New thieno[2,3-b]pyridine-fused [1,2,4]triazolo[4,3-a]pyrimidinones were obtained by the [5+1] heterocyclization of the appropriate thieno[2,3-b]pyridines followed by the Smiles-type reaction protocol. In general, the triazoles tested exhibited better antibacterial activity against Gram-positive than against Gram-negative bacterial strains. Compoundscontaining 3-acetyl-1-(4-methoxyphenyl)[1,2,4]triazole unit demonstrated more potent inhibitory activities than the reference Linezolid.
Образец цитирования:
Sh. M. Sanad, A. E. Mekky, A. Y. Said, M. A. Elneairy, “New thieno[2,3-b]pyridine-fused [1,2,4]triazolo[4,3-a]pyrimidinone hybrids as potential MRSA and VRE inhibitors”, Mendeleev Commun., 31:3 (2021), 370–372
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https://www.mathnet.ru/rus/mendc933
https://www.mathnet.ru/rus/mendc/v31/i3/p370
Эта публикация цитируется в следующих 21 статьяx:
A. S. Skrylkova, D. M. Egorov, A. V. Egorova, A. A. Manshina, “Approaches to the Synthesis of 1,2,4-Triazolo[4,3-a]pyrimidines (Mini-Review)”, Russ J Gen Chem, 95:1 (2025), 44
Vidya Sagar Reddy Avuthu, Tejeswara Rao Allaka, Naveen Kushwaha, Pilli Veera Venkata Nanda Kishore, “Efficient Synthesis, Anticancer Evaluation of Triazole‐Thiadiazole/Benzo[d]Oxazole Scaffolds, and Investigation of Their Reactivity Properties Using Density‐Functional Theory Calculations and In Silico Docking”, Chemistry & Biodiversity, 2025
Ranjay Shaw, Ritu Tewari, Monika Yadav, Ekta Pandey, Khyati Tripathi, Jyoti Rani, Ismail Althagafi, Ramendra Pratap, “Recent advancements in the synthesis of fused thienopyridines and their therapeutic applications”, European Journal of Medicinal Chemistry Reports, 12 (2024), 100185
Noof A. Alenazi, Haifa Alharbi, Ahmad Fawzi Qarah, Amerah Alsoliemy, Matokah M. Abualnaja, Alaa Karkashan, Basma Abbas, Nashwa M. El-Metwaly, “New thieno[2,3-b]pyridine-based compounds: Synthesis, molecular modelling, antibacterial and antifungal activities”, Arabian Journal of Chemistry, 16:11 (2023), 105226
Ojasvi Gupta, Tathagata Pradhan, Gita Chawla, “An updated review on diverse range of biological activities of 1,2,4-triazole derivatives: Insight into structure activity relationship”, Journal of Molecular Structure, 1274 (2023), 134487
Sherif M.H. Sanad, Ahmed E.M. Mekky, “New bis(thieno[2,3-b]pyridine) hybrids linked to arene units as potential bacterial biofilm and MRSA inhibitors”, Can. J. Chem., 101:8 (2023), 538
Ahmed M. Abdelfattah, Sherif M. H. Sanad, Ahmed E. M. Mekky, “Regioselective synthesis and antibacterial screening of new thiazol-2(3H)-imines linked to arene or chromene units”, Synthetic Communications, 53:17 (2023), 1398
Sherif M. H. Sanad, Ahmed E. M. Mekky, “Three-component regioselective synthesis and antibacterial evaluation of new arene-linked bis(pyrazolo[1,5-a]pyrimidine) hybrids”, Synthetic Communications, 53:9 (2023), 658
Sherif M. H. Sanad, Ahmed E. M. Mekky, “Tandem synthesis and antibacterial screening of new thieno[2,3-b]pyridine-fused pyrimidin-4(3H)-ones linked to thiazole or oxazole units”, Synthetic Communications, 53:13 (2023), 994
Ahmed A. M. Ahmed, Ahmed E. M. Mekky, Sherif M. H. Sanad, “New piperazine-based bis(thieno[2,3-b]pyridine) and bis(pyrazolo[3,4-b]pyridine) hybrids linked to benzofuran units: Synthesis and in vitro screening of potential acetylcholinesterase inhibitors”, Synthetic Communications, 52:6 (2022), 912
Ahmed E. M. Mekky, Tamer T. El‐Idreesy, Sherif M. H. Sanad, “Chloramine Trihydrate‐Mediated Tandem Synthesis of New Pyrrole and/or Arene‐Linked Mono‐ and Bis(1,3,4‐Oxadiazole) Hybrids as Potential Bacterial Biofilm and MRSA Inhibitors”, Chemistry & Biodiversity, 19:8 (2022)
Ahmed E. M. Mekky, Sherif M. H. Sanad, “Microwave-assisted synthesis of nicotinonitrile and/or arene-linked bis(chromene-thiazoles) as new VRE and MRSA inhibitors”, Synthetic Communications, 52:24 (2022), 2276
Ahmed A. M. Ahmed, Ahmed E. M. Mekky, Sherif M. H. Sanad, “Effective synthesis of new benzo-fused macrocyclic and heteromacrocyclic bis(Schiff bases)”, J IRAN CHEM SOC, 19:5 (2022), 1711
Ahmed E. M. Mekky, Sherif M. H. Sanad, “New thiazole-based bis(Schiff bases) linked to arene units as potential MRSA inhibitors”, Synthetic Communications, 52:23 (2022), 2205
Sherif M.H. Sanad, Ahmed E.M. Mekky, Tamer T. El-Idreesy, “Potential bacterial biofilm, MRSA, and DHFR inhibitors based on new morpholine-linked chromene-thiazole hybrids: One-pot synthesis and in silico study”, Journal of Molecular Structure, 1248 (2022), 131476
Gurumallappa, J. Jayashankar, M.K. Hema, C.S. Karthik, D. Suma, S.R. Kumaraswamy, N.K. Lokanath, P. Mallu, M. Nethaji, N. Lu, “Enchant O H⋅⋅⋅O interactions in hydrated 6-amino-2-methoxypyrimidin-4(3H)one resembles as water flow in the channel: Crystallographic and theoretical investigations”, Journal of Molecular Structure, 1263 (2022), 133098
A. E. Mekky, Sh. M. Sanad, A. M. Abdelfattah, “Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis(1,3,4-oxadiazoles) linked to arene units”, Mendeleev Commun., 32:5 (2022), 612–614
Sherif M.H. Sanad, Ahmed E.M. Mekky, “New pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one hybrids linked to arene units: synthesis of potential MRSA, VRE, and COX-2 inhibitors”, Can. J. Chem., 99:11 (2021), 900
Mohamed A. Mohamed Teleb, Ahmed E. M. Mekky, Sherif M. H. Sanad, “3‐Aminothieno[2,3‐b]pyridine‐2‐carboxylate: Effective precursor for microwave‐assisted three components synthesis of new pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4(3H)‐one hybrids”, Journal of Heterocyclic Chem, 58:9 (2021), 1825
Ahmed E. M. Mekky, Sherif M. H. Sanad, Tamer T. El-Idreesy, “New thiazole and thiazole-chromene hybrids possessing morpholine units: Piperazine-mediated one-pot synthesis of potential acetylcholinesterase inhibitors”, Synthetic Communications, 51:21 (2021), 3332
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