Аннотация:
A series of novel 3-azolylandrosta-3,5-dienes was prepared via Cu-catalyzed Ullmann C–N coupling between a readily available steroidal vinyliodide and a variety of NH-heterocycles. The cytotoxic activity of the target compounds was evaluated against selected cancer cell lines (MCF-7, SKOV-3, DU-145, PC-3). Compound bearing gramine fragment showed the highest antiproliferative effect with IC50 values in the range of 2.0–10.1μm.
Образец цитирования:
M. J. Parulava, Yu. N. Kotovshchikov, G. V. Latyshev, D. V. Sokolova, I. P. Beletskaya, N. V. Lukashev, “Synthesis of novel cytotoxic 3-azolylsteroids via Cu-catalyzed C–N coupling”, Mendeleev Commun., 31:3 (2021), 359–361
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc929
https://www.mathnet.ru/rus/mendc/v31/i3/p359
Эта публикация цитируется в следующих 3 статьяx:
Mikhail J. Parulava, Yury N. Kotovshchikov, Gennadij V. Latyshev, Darina V. Sokolova, Nikolay V. Lukashev, Irina P. Beletskaya, “A General Route to 3-Thiosubstituted Steroids via Copper-Catalyzed C–S Coupling”, Synthesis, 2025
A. V. Komkov, L. G. Menchikov, A. S. Dmitrenok, I. V. Zavarzin, “Synthesis of androstane derivatives fused with polyheterocycles at the D ring”, Mendeleev Commun., 33:6 (2023), 782–783
Yury N. Kotovshchikov, Artem A. Binyakovsky, Gennadij V. Latyshev, Nikolay V. Lukashev, Irina P. Beletskaya, “Copper-catalyzed deacetonative Sonogashira coupling”, Org. Biomol. Chem., 20:38 (2022), 7650
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