Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl

Using bio-Strips and cytotoxicity potentials, the least and most harmful substances involved in the synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl from 4-methoxyphenyl- boronic acid and aryl halide were identified. A total of 36 synthetic routes were analyzed.