Аннотация:
A three-component protocol was adopted to efficiently prepare new bis(pyrazolo[1,5-a]pyrimidines) linked to different spacers in 80-92% yields from 1H-pyrazole-3,5-diamines, malononitrile and bis(aldehydes). The p-xylene-linked bis(pyrimidine) bearing 3-positioned 4-methoxy-benzyl substituent had the best antibacterial activity with MIC / MBC values up to 2.2 / 4.4 µm.
Образец цитирования:
A. E. M. Mekky, Sh. M. H. Sanad, “Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers”, Mendeleev Commun., 33:3 (2023), 331–333
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc388
https://www.mathnet.ru/rus/mendc/v33/i3/p331
Эта публикация цитируется в следующих 9 статьяx:
Zeinab A. Abdallah, Ahmed M. Abdelfattah, Ahmed A.M. Ahmed, “Benzo[6,7]cyclohepta[1,2-d]pyrazolo[1,5-a]pyrimidines: Regioselective synthesis of a Novel Ring System, DFT-based NMR prediction, local reactivity indexes, and MEP analysis”, Journal of Molecular Structure, 1321 (2025), 140030
Ahmed A. M. Ahmed, Ahmed E. M. Mekky, Sherif M. H. Sanad, “Synthesis of new bis(pyrazolo[1,5-
a
]pyrimidines) linked to different spacers with potential MurB inhibitory activity utilizing 1
H
-pyrazole-3,5-diamines”, Synthetic Communications, 55:1 (2025), 19
Ahmed A. M. Ahmed, Ahmed E. M. Mekky, Sherif M. H. Sanad, “New thiazole-based pyrazolo[1,5-
a
]pyrimidine hybrids: One-pot synthesis of potential MRSA and VRE inhibitors”, Synthetic Communications, 55:7 (2025), 550
Ahmed E. M. Mekky, Sherif M. H. Sanad, “New Bis(pyrazolo[5,1‐b]quinazolines) and Bis(9H‐xanthenediones) Linked to Alkane Cores: One‐Pot Synthesis, Antibacterial Screening, and SAR Study”, Chemistry & Biodiversity, 2024
Mohamed A. A. Elneairy, Emad G. N. Youssef, Sama A. A. Ebrahim, Nour E. M. Mohammad, Nourhan M. S. Abd El‐Rahman, Ahmed S. M. Elhewaty, Sherif M. H. Sanad, Ahmed E. M. Mekky, “MRSA Inhibitory Activity of Some New Pyrazolo[1,5‐a]pyrimidines Linked to Arene and/or Furan or Thiophene Units”, Chemistry & Biodiversity, 2024
Sherif M. H. Sanad, Ahmed E. M. Mekky, “Potential MRSA inhibitory activity of some new benzofuran-pyrazolo[1,5-
a
]pyrimidine hybrids attached to arene units
via
methylene or azo linkage”, Synthetic Communications, 54:21 (2024), 1857
I. I. Butorin, O. A. Konovalova, P. A. Slepukhin, S. K. Kotovskaya, V. L. Rusinov, “An alternative synthesis of 7-amino-6-nitro-substituted azolo[1,5-a]pyrimidines”, Mendeleev Commun., 34:5 (2024), 706–708
Ahmed M. Abdelfattah, Sherif M. H. Sanad, Ahmed E. M. Mekky, “Regioselective synthesis and antibacterial screening of new thiazol-2(3H)-imines linked to arene or chromene units”, Synthetic Communications, 53:17 (2023), 1398
Sherif M. H. Sanad, Alshimaa A. M. Abdelsalam, Aya A. Gamal Eldin, Esraa H. Abdelfattah, Fatma R. M. Hussein, Nada G. Mohammed, Nariman A. S. Taha, Ahmed E. M. Mekky, “Synthesis of New Bis(pyrazolo[1,5‐a]pyrimidines) Linked to Different Spacers as Potential MurB Inhibitors”, Chemistry & Biodiversity, 20:6 (2023)
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