Аннотация:
An efficient synthesis of 8-bromo-7-chloropyrido[1,2-a]-benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue from N-(4-chloro-2-nitrophenyl)pyridinium chloride has been accomplished. The study for antitumour activity against cancer cell lines such as A549, SH-SY5Y, Hep-2, HeLa and MCF-7 revealed that the cytotoxic effect of the compounds obtained was several times higher than that of Mitomycin C.
Образец цитирования:
R. S. Begunov, Yu. R. Aleksandrova, E. Yu. Yandulova, N. S. Nikolaeva, M. E. Neganova, “Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue”, Mendeleev Commun., 33:2 (2023), 237–239
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc361
https://www.mathnet.ru/rus/mendc/v33/i2/p237
Эта публикация цитируется в следующих 1 статьяx:
R. S. Begunov, A. V. Chetvertakova, M. E. Neganova, “Regioselective synthesis of 2-(1H-benzimidazol-1-yl)-5-nitro- and 2-(5-nitro-1H-benzimidazol-1-yl)anilines”, Mendeleev Commun., 33:5 (2023), 650–652
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