Аннотация:
The synthetic approach to 6'SiaLec and its 6-O-Su derivative comprised α-sialylation of a protected Lec derivative, 2,3-di-OAcGalβ1-3(3-OAc-6-OBn)GlcNAcβ1-Osp (68% yield) as the key stage. Deprotection of the obtained trisaccharide (three stages, 79% overall yield) led to Neu5Acα2-6Galβ1-3GlcNAcβ1-Osp; partial deprotection followed by selective sulfation and total deprotection – to Neu5Acα2-6Galβ1-3(6-O-Su)GlcNAcβ1-Osp (four stages, 72% overall yield).
Ключевые слова:
Lewis C trisaccharide, sulfation, sialylation.
Тип публикации:
Статья
Язык публикации: английский
Образец цитирования:
G. V. Pazynina, I. S. Popova, I. M. Belyanchikov, A. B. Tuzikov, N. V. Bovin, “Synthesis of trisaccharide 6’ SiaLec and its 6-O-Su derivative”, Mendeleev Commun., 22:4 (2012), 194–195
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc2787
https://www.mathnet.ru/rus/mendc/v22/i4/p194
Эта публикация цитируется в следующих 3 статьяx:
Galina Pazynina, Marina Sablina, Tatiana Ovchinnikova, Tatiana Tyrtysh, Svetlana Tsygankova, Alexander Tuzikov, Kira Dobrochaeva, Nadezhda Shilova, Nailia Khasbiullina, Nicolai Bovin, “Synthetic glyco-O-sulfatome for profiling of human natural antibodies”, Carbohydrate Research, 445 (2017), 23
David J. Harvey, “Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2011–2012”, Mass Spectrometry Reviews, 36:3 (2017), 255
G. V. Pazynina, S. V. Tsygankova, M. A. Sablina, A. S. Paramonov, A. B. Tuzikov, N. V. Bovin, “Stereo- and regioselective synthesis of spacer armed α2-6 sialooligosaccharides”, Mendeleev Commun., 26:5 (2016), 380–382
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