Regioselective arylation of (het)aryl fragment in 2-(het)aryl-1-methylperimidines under ruthenium catalysis

The ruthenium-catalyzed reaction of 2-(het)aryl-1-methylperimidines with aryl bromides proceeds as regioselective C–H ortho-arylation of the (het)aryl fragment, perimidine core acting as a directing group. The reaction is selective and tolerates to different functional groups in aryl bromide thus allowing further functionalization of the obtained products.