Аннотация:
A new 3-hydroxy-4-pyridinone ligand, viz. N-(3-hydroxy-2-methyl-4-oxo-4H-pyridin-1-yl)isonicotinamide bearing isoniazid fragment, was synthesized and characterized. The differences in molecular and electronic structures of the product compared to the parent isoniazid (INH) were revealed by X-ray diffraction and DFT calculations. They are responsible for a dramatic decrease in the antimyco- bacterial activity of the product in comparison with INH.
Образец цитирования:
M. A. Katkova, G. S. Zabrodina, R. V. Rumyantcev, G. Yu. Zhigulin, I. V. Skabitsky, I. G. Fomina, O. B. Bekker, S. Yu. Ketkov, I. L. Eremenko, “Insight into design of 3-hydroxy-4-pyridinone functionalized with isoniazid fragment: structural characterization and antimycobacterial evaluation”, Mendeleev Commun., 34:6 (2024), 850–853