Аннотация:
The investigation of antibacterial activity of three-finger cobra cytotoxins towards Gram-negative and Gram-positive bacteria showed no activity against the former species, whereas M. luteus from the latter ones was the most susceptible to cytotoxins. A correlation was revealed between this activity and hydrophobicity of the toxins (HTL scores), total charge and its distribution over the toxin molecule: the absence of Glu-16 residue and the presence of positively charged residues (Lys30/His31) in the tip of the loop 2.
Тип публикации:
Статья
Язык публикации: английский
Образец цитирования:
P. V. Dubovskii, O. V. Vorontsova, Yu. N. Utkin, A. S. Arsen'ev, R. G. Efremov, A. V. Feofanov, “Cobra cytotoxins: determinants of antibacterial activity”, Mendeleev Commun., 25:1 (2015), 70–71
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc2305
https://www.mathnet.ru/rus/mendc/v25/i1/p70
Эта публикация цитируется в следующих 6 статьяx:
Peter V. Dubovskii, Yuri N. Utkin, “Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These Toxins”, Toxins, 16:6 (2024), 262
Peter V. Dubovskii, Anastasia A. Ignatova, Anna S. Alekseeva, Vladislav G. Starkov, Ivan A. Boldyrev, Alexey V. Feofanov, Yuri N. Utkin, “Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop”, Toxins, 15:1 (2022), 6
Peter V. Dubovskii, Anastasia A. Ignatova, Alexey V. Feofanov, Yuri N. Utkin, Roman G. Efremov, “Antibacterial activity of cardiotoxin-like basic polypeptide from cobra venom”, Bioorganic & Medicinal Chemistry Letters, 30:3 (2020), 126890
Peter V. Dubovskii, Roman G. Efremov, “The role of hydrophobic /hydrophilic balance in the activity of structurally flexible vs. rigid cytolytic polypeptides and analogs developed on their basis”, Expert Review of Proteomics, 15:11 (2018), 873
Peter V. Dubovskii, Maxim A. Dubinnyi, Anastasia G. Konshina, Ekaterina D. Kazakova, Galina M. Sorokoumova, Tatyana M. Ilyasova, Mikhail A. Shulepko, Rita V. Chertkova, Ekaterina N. Lyukmanova, Dmitry A. Dolgikh, Alexander S. Arseniev, Roman G. Efremov, “Structural and Dynamic “Portraits” of Recombinant and Native Cytotoxin I from Naja oxiana: How Close Are They?”, Biochemistry, 56:34 (2017), 4468
Peter V. Dubovskii, Alexander A. Vassilevski, Sergey A. Kozlov, Alexey V. Feofanov, Eugene V. Grishin, Roman G. Efremov, “Latarcins: versatile spider venom peptides”, Cell. Mol. Life Sci., 72:23 (2015), 4501
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