Аннотация:
Cyanopropargylic alcohols (4-hydroxyalk-2-ynenitriles) add cytosine at the triple bond under mild conditions (3–5 mol% K2CO3, DMF, 20–25°C, 2–3 h) to afford regio- and stereoselectively the Michael adducts, (Z)-3-[4-amino-2-oxo-1(2H)-pyrimidinyl]-4-hydroxy-4-alkylalk-2-enenitriles, in80–88% yield.
Образец цитирования:
A. G. Mal'kina, V. V. Nosyreva, O. A. Shemyakina, A. I. Albanov, B. A. Trofimov, “Regio- and stereoselective modification of cytosine with cyanopropargylic alcohols”, Mendeleev Commun., 27:1 (2017), 14–15