Аннотация:
Cyanopropargylic alcohols (4-hydroxyalk-2-ynenitriles) add cytosine at the triple bond under mild conditions (3–5 mol% K2CO3, DMF, 20–25°C, 2–3 h) to afford regio- and stereoselectively the Michael adducts, (Z)-3-[4-amino-2-oxo-1(2H)-pyrimidinyl]-4-hydroxy-4-alkylalk-2-enenitriles, in80–88% yield.
Образец цитирования:
A. G. Mal'kina, V. V. Nosyreva, O. A. Shemyakina, A. I. Albanov, B. A. Trofimov, “Regio- and stereoselective modification of cytosine with cyanopropargylic alcohols”, Mendeleev Commun., 27:1 (2017), 14–15
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1880
https://www.mathnet.ru/rus/mendc/v27/i1/p14
Эта публикация цитируется в следующих 2 статьяx:
Boris A. Trofimov, Anastasiya G. Mal'kina, “Cyanoacetylenic Alcohols: Molecules of Interstellar Relevance in the Synthesis of Essential Heterocycles, Amino Acids, Nucleobases and Nucleosides”, Synthesis, 53:16 (2021), 2740
B. A. Trofimov, K. V. Belyaeva, L. V. Andriyankova, L. P. Nikitina, A. G. Mal'kina, “Ring-opening of pyridines and imidazoles with electron-deficient acetylenes: En route to metal-free organic synthesis”, Mendeleev Commun., 27:2 (2017), 109–115
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