Аннотация:
Selective ligands of an urea-based prostate specific membrane antigen with a phenylalanine/tyrosine-based dipeptide linker and with a mingled chiral centers configuration and/or substituted aromatic fragments were prepared in seven steps by liquid- and in six steps by solid-phase synthesis. In vitro test for inhibiting the cleavage of N-acetylaspartylglutamate revealed the optimum linker containing l-phenylalanine in the structure on the N-terminus of a dipeptide chain.
Ключевые слова:
peptide synthesis, target drug delivery, prostate cancer, prostate specific membrane antigen, solid-phase synthesis, amides.
Образец цитирования:
A. A. Uspenskaia, A. E. Machulkin, E. A. Nimenko, R. R. Shafikov, S. A. Petrov, D. A. Skvortsov, E. K. Beloglazkina, A. G. Majouga, “Influence of the dipeptide linker configuration on the activity of PSMA ligands”, Mendeleev Commun., 30:6 (2020), 756–759
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1315
https://www.mathnet.ru/rus/mendc/v30/i6/p756
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