Аннотация:
The development of effective methods for real-time monitoring of nitroreductase (NTR) activity is of great significance for medical diagnosis and cancer research. Here, we present a novel water-soluble BODIPY-based chemodosimeter (NBB) for imaging the hypoxic status of human non-small-cell lung cancer A549 cells. We assume that ‘on–off’ response of NBB is activated by the NTRmediated reductive release of meso-phenol BODIPY dye resulting in unusual fluorescence.
Образец цитирования:
S. A. Gorbatov, D. Yu. Uvarov, A. M. Scherbakov, I. V. Zavarzin, Yu. A. Volkova, A. Romieu, “A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells”, Mendeleev Commun., 30:6 (2020), 750–752
Chandra Sekhara Mahanta, Velayutham Ravichandiran, Sharada Prasanna Swain, “Recent Developments in the Design of New Water-Soluble Boron Dipyrromethenes and Their Applications: An Updated Review”, ACS Appl. Bio Mater., 6:8 (2023), 2995
N. Yu. Zyk, S. A. Petrov, M. V. Zavertkina, A. A. Uspenskaya, P. A. Krasnikov, N. S. Volkova, E. K. Beloglazkina, A. G. Majouga, N. V. Zyk, A. E. Machulkin, “Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation”, Mendeleev Commun., 33:4 (2023), 472–475
V. F. Traven', D. A. Cheptsov, S. M. Dolotov, I. V. Ivanov, D. V. Khudyakov, V. A. Barachevskiǐ, “7-Dialkylamino-3-[1,5-diaryl(3-pyrazolinyl)]coumarins: two-photon absorption in solution and in polymer film”, Mendeleev Commun., 31:4 (2021), 520–522
Обратная связь: