Effect of L- or D,L-leucine content on self-assembly and properties of its amphiphilic copolymers with L-lysine

Copolymers of l-lysine and l/d,l-leucine differing in amino acid composition were synthesized and characterized for their self-assembly into nanoparticles. The effect of polypeptide composition on critical aggregation concentration, hydrodynamic diameter of nanoparticles, their stability and cytotoxicity was explored and discussed.