Аннотация:
A three-component protocol involving the reaction of 3-aminothieno[2,3-b]pyridine-2-carboxylate, Me2NCH(OMe)2 and heteroaryl (bis)amines in dioxane under microwave irradiation yielded a new series of pyrimidinones. The target hybrids were formed by an initial formamidine formation,Pyrazole-linked pyrimidinones displayed the best antibacterial activity against all the gram-positive and negative strains tested.
Ключевые слова:
cross-imidination, formamidines, [5+1] heterocyclization, in vitro antibacterial screening, microwave-assisted reactions, multicomponent reactions, pyrimidinones, tandem reactions, thieno[2,3-b]pyridines.
Образец цитирования:
Sh. M. Sanad, A. E. Mekky, “Synthesis and antibacterial evaluation of new pyrido[3',2':4,5]thieno[3,2-d ]pyrimidin-4(3H)-one hybrids linked to different heteroarene units”, Mendeleev Commun., 31:6 (2021), 862–864
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1068
https://www.mathnet.ru/rus/mendc/v31/i6/p862
Эта публикация цитируется в следующих 17 статьяx:
Mohamed A. A. Elneairy, Emad G. N. Youssef, Sama A. A. Ebrahim, Nour E. M. Mohammad, Nourhan M. S. Abd El‐Rahman, Ahmed S. M. Elhewaty, Sherif M. H. Sanad, Ahmed E. M. Mekky, “MRSA Inhibitory Activity of Some New Pyrazolo[1,5‐a]pyrimidines Linked to Arene and/or Furan or Thiophene Units”, Chemistry & Biodiversity, 2024
Sherif M. H. Sanad, Ahmed E. M. Mekky, “Potential MRSA inhibitory activity of some new benzofuran-pyrazolo[1,5-
a
]pyrimidine hybrids attached to arene units
via
methylene or azo linkage”, Synthetic Communications, 54:21 (2024), 1857
Sherif M. H. Sanad, Ahmed E. M. Mekky, Ahmed A M. Ahmed, “Pyrazolo[5,1‐b]quinazolines and Their Bis‐analogues Linked to Different Spacers: Regioselective Synthesis, Antibacterial Screening and SwissADME Prediction Study”, ChemistrySelect, 8:22 (2023)
Ahmed A. M. Ahmed, Ahmed E. M. Mekky, Sherif M. H. Sanad, “Three‐component synthesis of arene‐linked pyrazolo[1,5‐a]pyrimidines”, Journal of Heterocyclic Chem, 60:10 (2023), 1815
Yuyu Ding, Yan Zhang, Longjia Yan, Li Liu, “New pyrimidinothiophene derivatives: Synthesis, spectroscopic analysis, X-ray, DFT calculation, biological activity studies and ADMET prediction”, Journal of Molecular Structure, 1290 (2023), 135952
Sherif M.H. Sanad, Ahmed E.M. Mekky, “New bis(thieno[2,3-b]pyridine) hybrids linked to arene units as potential bacterial biofilm and MRSA inhibitors”, Can. J. Chem., 101:8 (2023), 538
Zeinab A. Abdallah, Sherif M. H. Sanad, Ahmed E. M. Mekky, Mohamed S. Mohamed Ahmed, “New Arylazo‐Based (Chromene‐Thiazole) Hybrids as Potential MRSA Inhibitors”, Chemistry & Biodiversity, 20:4 (2023)
Sherif M. H. Sanad, Ahmed E. M. Mekky, “Tandem synthesis and antibacterial screening of new thieno[2,3-b]pyridine-fused pyrimidin-4(3H)-ones linked to thiazole or oxazole units”, Synthetic Communications, 53:13 (2023), 994
Sherif M. H. Sanad, Ahmed E. M. Mekky, “Three-component regioselective synthesis and antibacterial evaluation of new arene-linked bis(pyrazolo[1,5-a]pyrimidine) hybrids”, Synthetic Communications, 53:9 (2023), 658
Ahmed E. M. Mekky, Sherif M. H. Sanad, “Synthesis of New Pyrazolo[1,5‐a]pyrimidines as Potential Antibacterial Agents: In Vitro and In Silico Study”, ChemistrySelect, 8:17 (2023)
A. E. Mekky, Sh. M. Sanad, “Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers”, Mendeleev Commun., 33:3 (2023), 331–333
Sherif M. H. Sanad, Ahmed E. M. Mekky, “3‐Aminopyrazolo[3,4‐b]pyridine: Effective Precursor for Barium Hydroxide‐Mediated Three Components Synthesis of New Mono‐ and Bis(pyrimidines) with Potential Cytotoxic Activity”, Chemistry & Biodiversity, 19:1 (2022)
Ahmed E. M. Mekky, Tamer T. El‐Idreesy, Sherif M. H. Sanad, “Chloramine Trihydrate‐Mediated Tandem Synthesis of New Pyrrole and/or Arene‐Linked Mono‐ and Bis(1,3,4‐Oxadiazole) Hybrids as Potential Bacterial Biofilm and MRSA Inhibitors”, Chemistry & Biodiversity, 19:8 (2022)
Sherif M. H. Sanad, Ahmed E. M. Mekky, “Ultrasound‐Mediated Synthesis of New (Piperazine‐Chromene)‐Linked Bis(thieno[2,3‐b]pyridine) Hybrids as Potential Anti‐acetylcholinesterase”, ChemistrySelect, 7:41 (2022)
Ahmed M. Abdelfattah, Ahmed E. M. Mekky, Sherif M. H. Sanad, “Synthesis, antibacterial activity and in silico study of new bis(1,3,4-oxadiazoles)”, Synthetic Communications, 52:11-12 (2022), 1421
Ahmed E. M. Mekky, Sherif M. H. Sanad, “Microwave-assisted synthesis of nicotinonitrile and/or arene-linked bis(chromene-thiazoles) as new VRE and MRSA inhibitors”, Synthetic Communications, 52:24 (2022), 2276
Nadia Hanafy Metwally, Thoraya Hossam Koraa, Sherif Mohamed Hamed Sanad, “Green one-pot synthesis and in vitro antibacterial screening of pyrano[2,3-c]pyrazoles, 4H-chromenes and pyrazolo[1,5-a]pyrimidines using biocatalyzed pepsin”, Synthetic Communications, 52:8 (2022), 1139
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