Abstract:
The review summarizes physicochemical characteristics of the natural sesquiterpene peroxide artemisinin. The kinetic schemes of transformations of artemisinin radicals under anaerobic conditions are presented and analyzed. The sequence of radical reactions of artemisinin in the presence of oxygen is considered in detail. Special emphasis is given to the intramolecular chain oxidation resulting in the transformation of artemisinin into polyatomic hydroperoxide. The kinetic characteristics of elementary reaction steps involving alkyl, alkoxyl, and peroxyl radicals generated from artemisinin are discussed. The results of testing of artemisinin and its derivatives for the antimalarial activity and the scheme of the biochemical synthesis of artemisinin in nature are considered.
Received: 03.02.2010
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Document Type:
Article
Language: English
Original paper language: Russian
Citation:
E. T. Denisov, S. L. Solodova, T. G. Denisova, “Radical chemistry of artemisinin”, Usp. Khim., 79:11 (2010), 1065–1088; Russian Chem. Reviews, 79:11 (2010), 981–1003
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https://www.mathnet.ru/eng/rcr140
https://doi.org/10.1070/RC2010v079n11ABEH004143
https://www.mathnet.ru/eng/rcr/v79/i11/p1065
This publication is cited in the following 23 articles:
Jiayin Yu, Zhihao Guo, Jiachang Yan, Changxin Bu, Chang Peng, Cuie Li, Rui Mao, Jian Zhang, Zhi Wang, Shi Chen, Meicun Yao, Zhiyong Xie, Chuan Yang, Yi Yan Yang, Peiyan Yuan, Xin Ding, Advanced Science, 10:20 (2023)
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