Abstract:
The bioavailability improvement of hydrophobic drugs is one of the major problems in pharmaceutical research as required for the enhancement of their therapeutic efficacy. Encapsulation of such drugs into various micro- and nanocarriers enabling the targeted delivery represents an important strategy here. The process of the designed nanoformulation study generally includes characterization of the payload release profile in model water-based media, which provides a challenge to encapsulated hydrophobic drugs due to their poor solubility in water. Thus, modification of the existed release investigation protocols is required for reliable detection of the liberated hydrophobic drug. Here, we report an optimized multimodal spectroscopic and microscopic study of the release behaviour of griseofulvin (Gf), a water-insoluble antifungal drug, from vaterite carriers. The addition of N, N-dimethylformamide (DMF), a polar aprotic solvent, to aqueous suspensions of Gf-loaded vaterite carriers at the investigated time points right before the UV-Vis spectroscopic measurement allowed us to enhance the accuracy of the released Gf determination. Monitoring of the carrier degradation process by a combination of scanning electron microscopy and Raman spectroscopy demonstrated a good correlation between the obtained data and the payload release kinetics.
Citation:
M. S. Savelyeva, E. V. Lengert, A. M. Abramova, S. N. Shtykov, Yu. I. Svenskaya, “Spectroscopic study of the release kinetics of water-insoluble drug griseofulvin from vaterite containers in aqueous medium”, Optics and Spectroscopy, 129:6 (2021), 669–676; Optics and Spectroscopy, 129:7 (2021), 813–820
\Bibitem{SavLenAbr21}
\by M.~S.~Savelyeva, E.~V.~Lengert, A.~M.~Abramova, S.~N.~Shtykov, Yu.~I.~Svenskaya
\paper Spectroscopic study of the release kinetics of water-insoluble drug griseofulvin from vaterite containers in aqueous medium
\jour Optics and Spectroscopy
\yr 2021
\vol 129
\issue 6
\pages 669--676
\mathnet{http://mi.mathnet.ru/os109}
\crossref{https://doi.org/10.21883/OS.2021.06.50976.5k-21}
\elib{https://elibrary.ru/item.asp?id=46489741}
\transl
\jour Optics and Spectroscopy
\yr 2021
\vol 129
\issue 7
\pages 813--820
\crossref{https://doi.org/10.1134/S0030400X21060126}
Linking options:
https://www.mathnet.ru/eng/os109
https://www.mathnet.ru/eng/os/v129/i6/p669
This publication is cited in the following 4 articles:
Roman A. Verkhovskii, Anastasiia A. Kozlova, Ekaterina V. Lengert, Mariia S. Saveleva, Mikhail A. Makarkin, Artem M. Mylnikov, Nikita A. Navolokin, Alla B. Bucharskaya, Georgy S. Terentyuk, Ilya A. Bosak, Natalya V. Vasilyeva, Yulia I. Svenskaya, “Cytotoxicity, Dermal Toxicity, and In Vivo Antifungal Effect of Griseofulvin-Loaded Vaterite Carriers Administered via Sonophoresis”, ACS Infect. Dis., 9:5 (2023), 1137
Yulia I. Svenskaya, Ekaterina V. Lengert, Yana V. Tarakanchikova, Albert R. Muslimov, Mariia S. Saveleva, Elina A. Genina, Igor L. Radchenko, Liudmila A. Stepanova, Andrey V. Vasin, Gleb B. Sukhorukov, Liudmila M. Tsybalova, “Non-invasive transcutaneous influenza immunization using vaccine-loaded vaterite particles”, J. Mater. Chem. B, 11:17 (2023), 3860
Yulia Svenskaya, Tatiana Pallaeva, “Exploiting Benefits of Vaterite Metastability to Design Degradable Systems for Biomedical Applications”, Pharmaceutics, 15:11 (2023), 2574
Mariia S. Saveleva, Ekaterina V. Lengert, Roman A. Verkhovskii, Anatolii A. Abalymov, Anton M. Pavlov, Alexey V. Ermakov, Ekaterina S. Prikhozhdenko, Sergei N. Shtykov, Yulia I. Svenskaya, “CaCO3-based carriers with prolonged release properties for antifungal drug delivery to hair follicles”, Biomater. Sci., 10:12 (2022), 3323
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