Abstract:
Spherical nanoparticles based on the biocompatible and biodegradable poly(d,l-lactide-co-glycolide) copolymer (90 : 10) loaded with oxaliplatin were produced by nanoprecipitation. Effect of the oxaliplatin loading on structure, size and morphology of the copolymer particles is considered. The nanoformulation of oxaliplatin demonstrates enhanced cytotoxicity and selectivity in vitro against several cancer cells compared with the free drug.
Citation:
E. V. Kuznetsova, K. T. Kalinin, N. G. Sedush, A. A. Nazarov, D. S. Volkov, S. N. Chvalun, “Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin”, Mendeleev Commun., 31:4 (2021), 512–514
Linking options:
https://www.mathnet.ru/eng/mendc973
https://www.mathnet.ru/eng/mendc/v31/i4/p512
This publication is cited in the following 15 articles:
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Svetlana V. Rempel, Yulia V. Kuznetsova, Maria V. Ulitko, Andrey A. Rempel, “In vitro study of cytotoxicity of cadmium sulfide quantum dots in aqueous solutions”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 710 (2025), 136243
A. A. Puchkov, N. G. Sedush, A. A. Nazarov, S. N. Chvalun, “Physicochemical characteristics and antiproliferative activity of a water-soluble nanoformulation of the PtIV complex with a lonidamine-based ligand”, Russ Chem Bull, 73:1 (2024), 213
E. V. Kuznetsova, A. E. Tyurnina, E. A. Konshina, A. A. Atamanova, K. T. Kalinin, S. V. Aleshin, V. G. Shuvatova, G. A. Posypanova, S. N. Chvalun, “Effect of Stabilizer Concentration on Parameters of Poly(D,L-lactide-co-glycolide) Nanoparticles Produced by Nanoprecipitation”, Colloid J, 2024
A. I. Kulebyakina, I. A. Ivanov, K. T. Kalinin, P. V. Dmitryakov, A. N. Veleshko, K. V. Kondratyev, E. N. Poznyrev, T. E. Grigoriev, R. A. Aliev, S. N. Chvalun, “Influence of Gamma Radiation on the Stability and Properties of Poly(Lactide-Glycolide) Nanoparticles in an Aqueous Dispersion”, Nanotechnol Russia, 19:3 (2024), 446
Ekaterina V. Kuznetsova, Nikita G. Sedush, Yulia A. Puchkova, Sergei V. Aleshin, Evgeny V. Yastremsky, Alexey A. Nazarov, Sergei N. Chvalun, “Highly Stable Docetaxel-Loaded Nanoparticles Based on Poly(D,L-lactide)-b-Poly(ethylene glycol) for Cancer Treatment: Preparation, Characterization, and In Vitro Cytotoxicity Studies”, Polymers, 15:10 (2023), 2296
V. A. Dyatlov, V. G. Kharitonova, D. V. Kupriyanova, E. G. Krivoborodov, I. A. Derevnin, A. I. Kovalev, I. A. Khotina, “Oligomers based on cyanoacrylic acid esters”, Mendeleev Commun., 33:4 (2023), 565–567
A. M. Desyatskova, E. V. Kuznetsova, Yu. A. Puchkova, E. V. Yastremsky, A. V. Bakirov, P. V. Dmitryakov, A. I. Buzin, S. N. Chvalun, “Effect of stereocomplex formation between enantiomeric poly(l,l-lactide) and poly(d,d-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution”, Mendeleev Commun., 33:1 (2023), 86–89
Yu. A. Puchkova, N. G. Sedush, A. D. Ivanenko, V. G. Shuvatova, G. A. Posypanova, S. N. Chvalun, “Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-block-polylactide) copolymers with well-defined structure”, Mendeleev Commun., 33:3 (2023), 404–407
J. O. Kotova, N. S. Osipova, J. A. Malinovskaya, P. A. Melnikov, S. E. Gelperina, “Properties of core–shell nanoparticles based on PLGA and human serum albumin prepared by different methods”, Mendeleev Commun., 33:5 (2023), 676–678
E. S. Vorontsova, Yu. V. Kuznetsova, M. V. Ulitko, S. V. Rempel, “Properties and biocompatibility of colloid cadmium sulfide nanoparticles”, Mendeleev Commun., 33:2 (2023), 218–220
I. I. Preobrazhenskiy, V. I. Putlayev, “Ceramics based on double magnesium–sodium phosphates for bone regeneration”, Mendeleev Commun., 33:4 (2023), 531–533
E. V. Kuznetsova, N. M. Kuznetsov, K. T. Kalinin, P. V. Lebedev-Stepanov, A. A. Novikov, S. N. Chvalun, “The Role of Integrated Approach in the Determination of Nanoparticle Sizes in Dispersions”, Colloid J, 84:6 (2022), 704
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov, “Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects”, Gels, 8:6 (2022), 329
Ekaterina Razuvaeva, Nikita Sedush, Evgeniya Shirokova, Stanislav Moskvichev, Dmitry Streltsov, Sergei Chvalun, “Effect of preparation conditions on the size of nanoparticles based on poly(D,L-lactide-co-glycolide) synthesized with bismuth subsalicylate”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 648 (2022), 129198
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