A. S. Kritchenkov, M. N. Kurasova, A. A. Godzishevskaya, E. S. Mitrofanova, A. R. Egorov, N. Z. Yagafarov, M. J. Ballesteros Meza, A. G. Tskhovrebov, A. A. Artemjev, E. V. Andrusenko, V. N. Khrustalev, “High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles”, Mendeleev Commun., 31:4 (2021), 504

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Mendeleev Communications, 2021, Volume 31, Issue 4, Pages 504–506
DOI: https://doi.org/10.1016/j.mencom.2021.07.022 (Mi mendc970)

This article is cited in 11 scientific papers (total in 11 papers)

Communications

High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles

A. S. Kritchenkov^ab, M. N. Kurasova^a, A. A. Godzishevskaya^a, E. S. Mitrofanova^a, A. R. Egorov^a, N. Z. Yagafarov^ac, M. J. Ballesteros Meza^a, A. G. Tskhovrebov^a, A. A. Artemjev^a, E. V. Andrusenko^d, V. N. Khrustalev^ae

^a Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
^b Institute of Technical Acoustics, National Academy of Sciences of Belarus, Vitebsk, Republic of Belarus
^c N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
^d Department of Chemistry, Altay State University, Barnaul, Russian Federation
^e N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Full-text PDF (730 kB) Citations (11)

DOI: https://doi.org/10.1016/j.mencom.2021.07.022

Graphic abstract: High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles

Abstract: The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-molecular-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH₄. The derivative of moderate molecular weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin.

Keywords: chitosan, pyridoxal, nanoparticles, antibacterial activity, low toxicity.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(356.4 Kb)

Citation: A. S. Kritchenkov, M. N. Kurasova, A. A. Godzishevskaya, E. S. Mitrofanova, A. R. Egorov, N. Z. Yagafarov, M. J. Ballesteros Meza, A. G. Tskhovrebov, A. A. Artemjev, E. V. Andrusenko, V. N. Khrustalev, “High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles”, Mendeleev Commun., 31:4 (2021), 504–506

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This publication is cited in the following 11 articles:

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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