Abstract:
A new peptidomimetic conjugate of natural methionine and pyridine-2,6-dicarboxylate was synthesized and evaluated as a potential ligand for 97Ru radiopharmaceuticals. The distribution of this radiopharmaceutical in mice was investigated. A fundamental difference was found in the distribution and excretion of ruthenium complex and free ruthenium ion in the body, which suggests a difference in their transport pathways due to the stability of the complex in the body.
Citation:
N. E. Borisova, M. A. Orlova, V. A. Knizhnikov, V. K. Dolgova, M. D. Reshetova, A. P. Orlov, “First 97Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical”, Mendeleev Commun., 31:2 (2021), 207–209
Linking options:
https://www.mathnet.ru/eng/mendc880
https://www.mathnet.ru/eng/mendc/v31/i2/p207
This publication is cited in the following 8 articles:
A. V. Severin, D. O. Lapshin, V. Yu. Yaryshev, S. V. Maksimov, T. P. Trofimova, M. A. Orlova, “Features of physicochemical properties of the hydroxyapatite—ruthenium system depending on the stage of metal ion introduction into the cocrystallization process”, Russ Chem Bull, 73:4 (2024), 828
Barbara Happl, Marie Brandt, Theresa Balber, Katarína Benčurová, Zeynep Talip, Alexander Voegele, Petra Heffeter, Wolfgang Kandioller, Nicholas P. Van der Meulen, Markus Mitterhauser, Marcus Hacker, Bernhard K. Keppler, Thomas L. Mindt, “Synthesis and Preclinical Evaluation of Radiolabeled [103Ru]BOLD-100”, Pharmaceutics, 15:11 (2023), 2626
N. Yu. Zyk, S. A. Petrov, M. V. Zavertkina, A. A. Uspenskaya, P. A. Krasnikov, N. S. Volkova, E. K. Beloglazkina, A. G. Majouga, N. V. Zyk, A. E. Machulkin, “Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation”, Mendeleev Commun., 33:4 (2023), 472–475
Farzin Marandi, Keyvan Moeini, Sebastian Küsel, Harald Krautscheid, “Mononuclear and polymeric zinc(II) β-diketonate complexes with aromatic N-donor ligands: Structural, spectral, thermal, theoretical and docking studies”, Polyhedron, 218 (2022), 115757
A. P. Orlov, T. P. Trofimova, M. A. Orlova, “Transition metals, their organic complexes, and radionuclides promising for medical use”, Russ Chem Bull, 71:3 (2022), 415
M. R. Gonchar, F. S. Ninin, E. R. Milaeva, A. A. Nazarov, “Hydrolytically stable organometallic ruthenium complexes with glucose-based phosphite ligands”, Russ Chem Bull, 71:5 (2022), 962
V. K. Dolgova, A. V. Gopin, A. L. Nikolaev, A. P. Orlov, T. P. Trofimova, M. A. Orlova, “Enzymatic hydroxyapatite as a carrier for yttrium-90 and copper and ruthenium radionuclides”, Mendeleev Commun., 32:2 (2022), 281–282
M. A. Orlova, V. V. Spiridonov, G. A. Badun, T. P. Trofimova, A. P. Orlov, A. S. Zolotova, A. B. Priselkova, G. Yu. Aleshin, M. G. Chernysheva, A. A. Yaroslavov, S. N. Kalmykov, “In vivo behavior of carboxymethylcellulose based microgels containing 67Cu”, Mendeleev Commun., 32:5 (2022), 658–660
Contact us: