Abstract:
A novel electroneutral rigid meso-sulfophenyloxy substituted heptamethine dye was synthesized in six steps. Selective derivatization of one sulfonamide group with octanedioic acid introduced the carboxy end group attached through the hexamethylene linker, which provided the dye solubility in water. Absorbance of the dye in the near infrared region makes it promising for covalent labeling of biomolecules.
Citation:
V. E. Shershov, V. E. Kuznetsova, R. A. Miftakhov, S. A. lapa, A. A. Stomahin, E. N. Timofeev, I. V. Grechishnikova, A. S. Zasedatelev, A. V. Chudinov, “Derivatization of a rigid meso-substituted heptamethine cyanine dye”, Mendeleev Commun., 31:1 (2021), 70–72
Linking options:
https://www.mathnet.ru/eng/mendc837
https://www.mathnet.ru/eng/mendc/v31/i1/p70
This publication is cited in the following 4 articles:
Arjun Veliyil Prakash, Fares Yazabak, Iryna Hovor, Faina Nakonechny, Olesia Kulyk, Olga Semenova, Andrii Bazylevich, Gary Gellerman, Leonid Patsenker, “Highly efficient near-IR cyclohexene cyanine photosensitizers for antibacterial photodynamic therapy”, Dyes and Pigments, 211 (2023), 111053
A. S. Efimova, M. A. Ustimova, M. A. Maksimova, A. Yu. Frolova, V. I. Martynov, S. M. Deyev, A. A. Pakhomov, Yu. V. Fedorov, O. A. Fedorova, “Synthesis and optical characteristics of 4-styrylpyridinium dyes and their conjugates with antibody”, Mendeleev Commun., 33:3 (2023), 384–386
Jing Liu, Lingfeng Wang, Ronghua Shen, Jie Zhao, Ying Qian, “A novel heptamethine cyanine photosensitizer for FRET-amplified photodynamic therapy and two-photon imaging in A-549 cells”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 274 (2022), 121083
Jiaolong Wang, Chunlong Sun, Min Ji, Baoqin Wang, Peng Wang, Gaoxin Zhou, Bin Dong, Wen Du, Li Huang, Hongguo Wang, Lili Ren, “Design, synthesis and application of near-infrared fluorescence probe IR-780-Crizotinib in detection of ALK positive tumors”, Protein Expression and Purification, 187 (2021), 105952
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