Abstract:
Iron(iii) chloride has been found to serve as an efficient catalyst for a mechanochemical (ball milling) one-pot four- component cascade reaction of phenyl glyoxal, anilines, indoles and activated alkyne affording highly-substituted 3-(1H-pyrrol-2-yl)-1H-indoles. The procedure is beneficial because of mild conditions, easily available starting materials, cheap catalyst and possibility for scaling.
Citation:
A. Mukherjee, D. S. Kopchuk, S. Santra, A. Majee, G. V. Zyryanov, O. N. Chupakhin, “Iron(iii) chloride-catalyzed mechanochemical cascade synthesis of highly-substituted pyrrolyl indoles”, Mendeleev Commun., 32:5 (2022), 624–626
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