Abstract:
Immunofluorescent microscopy of cancer cells A549 treated with novel alicyclic (mostly bridged) podophyllotoxin C4-esters at different concentrations gave evidence that the ‘curling’ of microtubules occurred at one of the first steps of their depolymerisation. Molecular dynamics study revealed the differences in curved conformations of tubulin dimer in a complex with adamantane-comprising ester and in a complex with podophyllotoxin.
Citation:
N. A. Zefirov, A. Glassl, E. V. Radchenko, A. N. Borovik, V. V. Stanishevskiy, E. R. Milaeva, S. A. Kuznetsov, O. N. Zefirova, “Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells”, Mendeleev Commun., 32:2 (2022), 173–175
Linking options:
https://www.mathnet.ru/eng/mendc603
https://www.mathnet.ru/eng/mendc/v32/i2/p173
This publication is cited in the following 9 articles:
A. N. Proshin, T. P. Trofimova, A. A. Globa, E. S. Dubrovskaya, O. N. Zefirova, N. A. Zefirov, V. A. Tafeenko, T. Ya. Dutova, B. I. Ugrak, I. V. Serkov, “New 1,1-dibenzyl-3-(1-benzyl-1H-pyrazol-4-yl)-2-methylisothioureas: synthesis and evaluation of antioxidant activity”, Russ Chem Bull, 73:5 (2024), 1399
Nasim Yousefipour, Hassan Hassani Kumleh, Fazlolah Eshghi, Mohammad Hossein Rezadoost, Homeira Eshghi, “In silico design of a new Podophyllotoxin derivative with potent anti-tubulin activity”, Molecular Physics, 122:18 (2024)
N. A. Zefirov, E. V. Khvatov, E. V. Nurieva, Ya. L. Esaulkova, A. S. Volobueva, V. V. Zarubaev, A. S. Goryashchenko, D. O. Yatsenko, V. I. Uvarova, D. I. Osolodkin, A. A. Ishmukhametov, O. N. Zefirova, “Rimantadine derivatives with antiviral activity against flaviviruses and rimantadine-resistant strain of influenza A virus”, Russ Chem Bull, 73:6 (2024), 1801
O. A. Deeva, A. S. Pantileev, O. Yu. Kravtsova, S. V. Nikolaev, N. A. Zefirov, P. Yu. Povarnina, T. A. Antipova, T. A. Gudasheva, V. L. Dorofeev, “Tripeptide Phe-Trp-Leu-NH2 as a putative endogenous ligand of TSPO: molecular modeling, synthesis and pharmacological activity”, Mendeleev Commun., 34:5 (2024), 682–684
E. V. Nurieva, O. Yu. Kravtsova, A. V. Sydoriuk, E. V. Britikova, V. V. Britikov, N. A. Zefirov, E. R. Milaeva, O. N. Zefirova, “The homodimer approach to the design of a new long-acting depot prodrug of abiraterone”, Mendeleev Commun., 34:4 (2024), 502–504
I. A. Elisseev, E. V. Nurieva, N. A. Zefirov, A. Yu. Kolchanova, D. A. Skvortsov, E. R. Milaeva, O. N. Zefirova, “New C(4)-esters of podophyllotoxin and epipodophyllotoxin with heterocyclic moieties”, Russ Chem Bull, 72:9 (2023), 2191
N. A. Zefirov, E. V. Nurieva, A. V. Mamaeva, D. A. Vasilenko, K. S. Sadovnikov, E. B. Averina, A. Yu. Kolchanova, E. R. Milaeva, O. N. Zefirova, “New podophyllotoxin and epipodophyllotoxin derivatives with substituted isoxazole fragments”, Russ Chem Bull, 72:4 (2023), 1029
Yuqin Xu, Zihan He, Li Chen, Huai Wang, “Podophyllotoxin derivatives targeting tubulin: An update (2017–2022)”, Drug Discovery Today, 28:8 (2023), 103640
N. A. Zefirov, P. D. Korotkova, E. F. Shevtsova, P. N. Shevtsov, A. V. Mamaeva, E. R. Milaeva, O. N. Zefirova, “Role of structural components of the 2-methoxyestradiol—chlorambucil conjugate in microtubule stabilization”, Russ Chem Bull, 71:11 (2022), 2519
Contact us: