Abstract:
Methyl 4-trifluoro-2-isopropyl-4-oxobutanoate prepared by the improved procedure was cyclized with hydrazines to afford the title pyrazole derivatives. N- and O-alkylation of 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-ol gave trifluoromethyl analogues of Propyphenazone and 5-alkoxy derivatives. 4-Isopropylpyrazoles containing O-butoxy moiety with a terminal trifluoromethyl or acyloxy group were found to demonstrate a promising analgesic activity.
Citation:
L. S. Lapshin, E. V. Shchegolkov, Ya. V. Burgart, G. A. Triandafilova, O. P. Krasnykh, K. O. Malysheva, V. I. Saloutin, “Synthesis of new analgesics based on 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-one”, Mendeleev Commun., 33:2 (2023), 194–196
Linking options:
https://www.mathnet.ru/eng/mendc347
https://www.mathnet.ru/eng/mendc/v33/i2/p194
This publication is cited in the following 3 articles:
Luan A. Martinho, Carlos Kleber Z. Andrade, “Sustainable click reactions: Use of greener reaction media in the synthesis of 1,2,3-triazoles”, Tetrahedron, 157 (2024), 133964
Ranjana Aggarwal, Swati Sharma, “Recent advances in the synthesis of 3(5)-trifluoromethylpyrazoles”, Synthetic Communications, 54:2 (2024), 87
Yu. A. Kovygin, I. S. Zotova, N. M. Sotnikov, V. A. Polikarchuk, Kh. S. Shikhaliev, “Recyclization of N-arylitaconimides with hydrazines as a new effective synthesis of 2-(3-oxopyrazolidin-4-yl)acetanilides”, Mendeleev Commun., 34:2 (2024), 282–284
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