Abstract:
Four specially designed bicyclo[3.3.1]nonane-based structures were synthesised and found to be cytotoxic at micromolar concentrations and to cause slight non-specific tubulin aggregation.
Citation:
O. N. Zefirova, E. V. Nurieva, H. Lemcke, A. A. Ivanov, N. V. Zyk, D. G. Weiss, S. A. Kuznetsov, N. S. Zefirov, “Design, synthesis and bioactivity of simplified taxol analogues on the basis of bicyclo[3.3.1]nonane derivatives”, Mendeleev Commun., 18:4 (2008), 183–185
Linking options:
https://www.mathnet.ru/eng/mendc3289
https://www.mathnet.ru/eng/mendc/v18/i4/p183
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N. S. Baleeva, V. B. Rybakov, E. A. Ivleva, V. A. Shiryaev, Yu. N. Klimochkin, “Synthesis and Chemical Transformations of 7-Hydroxybicyclo[3.3.1]nonane-3-carbohydrazide”, Russ J Org Chem, 56:11 (2020), 1942
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N. A. Zefirov, A. Kruth, B. Wobith, E. V. Nurieva, S. Riyaz, Ch. Venkata Ramana Reddy, S. A. Kuznetsov, O. N. Zefirova, “Novel bridged and caged C4-podophyllotoxin derivatives as microtubule disruptors: synthesis, cytotoxic evaluation and structure–activity relationship”, Mendeleev Commun., 28:5 (2018), 475–478
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E. V. Nurieva, N. A. Zefirov, A. V. Mamaeva, Yu. K. Grishin, S. A. Kuznetsov, O. N. Zefirova, “Synthesis of non-steroidal 2-methoxyestradiol mimetics based on the bicyclo[3.3.1]nonane structural motif”, Mendeleev Commun., 27:3 (2017), 240–242
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E. V. Nurieva, N. A. Zefirov, N. S. Zefirov, S. A. Kuznetsov, O. N. Zefirova, “Synthesis and antiproliferative activity of combretastatin derivatives with adamantane fragment”, Russ Chem Bull, 64:9 (2015), 2248
N. A. Zefirov, Ya. S. Glazkova, I. V. Kuznetsova, E. V. Nurieva, O. N. Zefirova, “Molecular design and an attempt to synthesize a conjugate of 2-methoxyestradiol with adamantane”, Moscow Univ. Chem. Bull., 70:2 (2015), 69
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