Abstract:
The cyclocondensation of racemic valine, leucine and β-phenylalanine hydroxamic acids with acetone regioselectively affords corresponding cyclic hydroxamic acids; the crystal structure of the 5-isobutyl derivative was determined by X-ray diffraction analysis and compared with that of its 5-methyl homologue.
Citation:
I. V. Vystorop, Yu. V. Nelyubina, V. N. Voznesensky, W.-H. Sun, V. P. Lodygina, K. A. Lyssenko, R. G. Kostyanovsky, “General regioselective synthesis and crystal structure of racemic 5-substituted 2,2-dimethyl-3-hydroxyimidazolidin-4-ones”, Mendeleev Commun., 20:2 (2010), 106–108
Linking options:
https://www.mathnet.ru/eng/mendc3005
https://www.mathnet.ru/eng/mendc/v20/i2/p106
This publication is cited in the following 4 articles:
I. V. Vystorop, G. V. Shilov, A. V. Chernyak, E. N. Klimanova, T. E. Sashenkova, S. G. Klochkov, M. E. Neganova, Yu. R. Aleksandrova, U. Yu. Allayarova, D. V. Mishchenko, “Regioselective Synthesis, Structure, and Chemosensitizing Antitumor Activity of Cyclic Hydroxamic Acid Based on DL-Valine”, Russ J Bioorg Chem, 47:3 (2021), 757
N. P. Akentieva, A. R. Gizatullin, S. A. Goncharova, T. A. Raevskaya, N. S. Goryachev, N. I. Shkondina, T. R. Prichodchenko, I. V. Vystorop, S. S. Shushanov, “Anticancer Activity of Spirocyclic Hydroxamic Acids (Derivatives of 1-Hydroxy-1,4,8-Triazaspiro[4,5]Decan-2-One), Histone Deacetylase Inhibitors”, Biochem. Moscow Suppl. Ser. A, 13:1 (2019), 12
I. V. Vystorop, N. P. Konovalova, Yu. V. Nelyubina, A. V. Chernyak, T. E. Sashenkova, E. N. Klimanova, A. N. Utienyshev, B. S. Fedorov, G. V. Shilov, R. G. Kostyanovsky, “Cyclic hydroxamic acids derived from α-amino acids 2. Regioselective synthesis, crystal structure, and antitumor activity of spiropiperidine-imidazolidine hydroxamic acids based on glycine and dl-alanine”, Russ Chem Bull, 62:5 (2013), 1272
Igor V. Vystorop, Yulia V. Nelyubina, Vladimir N. Voznesensky, Wen‐Hua Sun, Vera P. Lodygina, Konstantin A. Lyssenko, Remir G. Kostyanovsky, “ChemInform Abstract: General Regioselective Synthesis and Crystal Structure of Racemic 5‐Substituted 2,2‐Dimethyl‐3‐hydroxyimidazolidin‐4‐ones.”, ChemInform, 41:49 (2010)
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