Abstract:
Macrocycle having two isosteviol moieties and malonate fragment has been synthesised, and its ability to inhibit the growth of Mycobacterium tuberculosis H37Rv in vitro with MIC value of 1mg cm–3 has been demonstrated. The macrocycle adds fullerene C60 at the activated methylene group to furnish the corresponding methanofullerene conjugate.
Citation:
R. N. Khaybullin, I. Yu. Strobykina, V. P. Gubskaya, G. M. Fazleeva, Sh. K. Latypov, V. E. Kataev, “New malonate macrocycle bearing two isosteviol moieties and its adduct with fullerene C60”, Mendeleev Commun., 21:3 (2011), 134–136
Linking options:
https://www.mathnet.ru/eng/mendc2891
https://www.mathnet.ru/eng/mendc/v21/i3/p134
This publication is cited in the following 11 articles:
Yulya N. Biglova, Akhat G. Mustafin, “Nucleophilic cyclopropanation of [60]fullerene by the addition–elimination mechanism”, RSC Adv., 9:39 (2019), 22428
Asad Ullah, Sidra Munir, Yahia Mabkhot, Syed Lal Badshah, “Bioactivity Profile of the Diterpene Isosteviol and its Derivatives”, Molecules, 24:4 (2019), 678
V. A. Vil', E. S. Gorlov, O. V. Bityukov, I. B. Krylov, G. I. Nikishin, K. K. Pivnitsky, A. O. Terent'ev, “Oxidative C–O coupling as a new idea in the 'click-like chemistry': malonyl peroxides for the conjugation of two molecules”, Mendeleev Commun., 29:2 (2019), 132–134
Bulat F. Garifullin, Irina Yu. Strobykina, Radmila R. Sharipova, Marionella A. Kravchenko, Olga V. Andreeva, Olga B. Bazanova, Vladimir E. Kataev, “Synthesis and antituberculosis activity of the first macrocyclic glycoterpenoids comprising glucosamine and diterpenoid isosteviol”, Carbohydrate Research, 431 (2016), 15
R. R. Sharipova, B. F. Garifullin, O. V. Andreeva, I. Yu. Strobykina, O. B. Bazanova, V. E. Kataev, “Macrocyclic derivatives of steviolbioside, a glycoside isolated from Stevia Rebaudiana”, Russ J Org Chem, 51:3 (2015), 424
I. Yu. Strobykina, M. G. Belenok, B. F. Garifullin, V. M. Babaev, V. E. Kataev, “Open-Chain and Macrocyclic Polyethyleneglycol Esters of the Diterpenoid Isosteviol”, Chem Nat Compd, 50:3 (2014), 462
O. V. Andreeva, V. M. Babaev, I. Kh. Rizvanov, I. Yu. Strobykina, V. E. Kataev, “Macrocyclic derivatives of isosteviol with two tetracyclic diterpenoid skeletons”, Russ J Gen Chem, 84:2 (2014), 304
B. F. Garifullin, R. R. Sharipova, I. Yu. Strobykina, V. M. Babaev, V. E. Kataev, “Synthetic glycosides containing two isosteviol fragments functionalized with D-glucopyranose”, Russ J Org Chem, 50:4 (2014), 484
I. Yu. Strobykina, V. M. Babaev, I. Kh. Rizvanov, V. E. Kataev, “Synthesis of Macrocyclic Derivatives of the Diterpenoid Isosteviol with Two and Four ent-Beyerane Frameworks”, Chem Nat Compd, 49:3 (2013), 462
A. B. Kornev, A. S. Peregudov, V. M. Martynenko, G. V. Guseva, T. E. Sashenkova, A. Yu. Rybkin, I. I. Faingold, D. V. Mishchenko, R. A. Kotelnikova, N. P. Konovalova, J. Balzarini, P. A. Troshin, “Synthesis and biological activity of a novel water-soluble methano[60]fullerene tetracarboxylic derivative”, Mendeleev Commun., 23:6 (2013), 323–325
Ravil N. Khaybullin, Irina Yu. Strobykina, Alexey B. Dobrynin, Aidar T. Gubaydullin, Regina V. Chestnova, Vasiliy M. Babaev, Vladimir E. Kataev, “Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol”, Bioorganic & Medicinal Chemistry Letters, 22:22 (2012), 6909
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