T. V. Rakitina, A. A. Zeifman, F. N. Novikov, O. V. Stroganov, V. S. Stroylov, I. Svitanko, A. Frank-Kamenetskii, G. G. Chilov, “Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro”, Mendeleev Commun., 25:5 (2015), 364

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Mendeleev Communications, 2015, Volume 25, Issue 5, Pages 364–366
DOI: https://doi.org/10.1016/j.mencom.2015.09.016 (Mi mendc2410)

This article is cited in 3 scientific papers (total in 3 papers)

Communications

Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro

T. V. Rakitina^ab, A. A. Zeifman^c, F. N. Novikov^c, O. V. Stroganov^c, V. S. Stroylov^c, I. Svitanko^cd, A. Frank-Kamenetskii^a, G. G. Chilov^c

^a National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
^b M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^d Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation

Full-text PDF (305 kB) Citations (3)

DOI: https://doi.org/10.1016/j.mencom.2015.09.016

Graphic abstract: Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro

Abstract: Six novel potential PARP1 inhibitors were identified by means of substructure search and molecular docking into PAPR1 active site; one compound (STK970217) potentiated the cytotoxicity of doxorubicin in hepatocellular carcinoma HepG2 cells being non-cytotoxic as a single agent, while three other identified compounds inhibited the growth of HepG2 cells both individually and in combination with doxorubicin.

Document Type: Article

Language: English

Citation: T. V. Rakitina, A. A. Zeifman, F. N. Novikov, O. V. Stroganov, V. S. Stroylov, I. Svitanko, A. Frank-Kamenetskii, G. G. Chilov, “Novel PARP1 inhibitors potentiate doxorubicin antitumor activity in vitro”, Mendeleev Commun., 25:5 (2015), 364–366

Linking options:

https://www.mathnet.ru/eng/mendc2410

https://www.mathnet.ru/eng/mendc/v25/i5/p364

This publication is cited in the following 3 articles:

Xiao‐Han Gao, Jun Yuan, Xiao‐Xia Zhang, Rui‐Cang Wang, Jie Yang, Yan Li, Jie Li, “Exploration of the Prognostic Markers of Multiple Myeloma Based on Cuproptosis‐Related Genes”, Cancer Reports, 8:3 (2025)
Ming Fang Hsu, Yen Sheng Tyan, Yu Chen Chien, Ming Wei Lee, “Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent”, Sci Rep, 8:1 (2018)
V. V. Abzianidze, K. P. Bolshakova, D. S. Prokofieva, A. O. Berestetskiy, V. A. Kuznetsov, Yu. G. Trishin, “Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity”, Mendeleev Commun., 27:1 (2017), 82–84

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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