Abstract:
Racemic Entecavir was prepared from Corey lactone diol benzylidene acetal in four steps in 24% overall yield.
Document Type:
Article
Language: English
Citation:
N. S. Vostrikov, I. F. Lobko, Z. R. Valiullina, M. S. Miftakhov, “Synthesis of racemic Entecavir”, Mendeleev Commun., 27:1 (2017), 12–13
Linking options:
https://www.mathnet.ru/eng/mendc1879
https://www.mathnet.ru/eng/mendc/v27/i1/p12
This publication is cited in the following 4 articles:
Z. R. Valiullina, N. A. Ivanova, M. S. Miftakhov, “Synthesis of (±)-Entecavir”, Russ J Org Chem, 60:3 (2024), 410
Guo-Tai Zhang, Gen Li, Linxi Wan, Xinxin Pu, Junhai Chang, Pei Tang, Fen-Er Chen, “Asymmetric Total Synthesis of Anti-HBV Drug Entecavir: Catalytic Strategies for the Stereospecific Construction of Densely Substituted Cyclopentene Cores”, Org. Lett., 26:22 (2024), 4818
Airat M. Gimazetdinov, Aidar Z. Al'mukhametov, Mansur S. Miftakhov, “Development of a new approach for the synthesis of (+)-15-deoxy-Δ12,14-prostaglandin J2 methyl ester based on the [2+2]-cycloadduct of 5-trimethylsilylcyclopentadiene and dichloroketene”, New J. Chem., 46:14 (2022), 6708
Huiying Wang, Qiuhua Wang, Yaling Wu, Lingping Cheng, Lunan Zhu, Junchen Zhu, Yanxiong Ke, “HPLC and SFC enantioseparation of (±)‐Corey lactone diol: Impact of the amylose tris‐(3,5‐dimethylphenylcarbamate) coating amount on chiral preparation”, Chirality, 31:10 (2019), 855
Contact us: