Abstract:
A new efficient method for the synthesis of 1,4-dihydroxy-2-naphthylmethyl-and 1,4-dioxo-2(1H,4H)-2-naphthylmethyl-phosphonium salts by reactions of 2-methyl-1,4-naphtho-quinone with appropriate P–H-phosphonium trifluoroacetates has been suggested. The reactions were carried out under mild conditions and provided high yields of target compounds. Representative reaction products have been found to possess moderate antimicrobial and antitumor activity.
Citation:
N. R. Khasiyatullina, V. F. Mironov, S. K. Gumerova, A. D. Voloshina, A. S. Sapunova, “Versatile approach to naphthoquinone phosphonium salts and evaluation of their biological activity”, Mendeleev Commun., 29:4 (2019), 435–437
Linking options:
https://www.mathnet.ru/eng/mendc1550
https://www.mathnet.ru/eng/mendc/v29/i4/p435
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D. V. Ponomaryov, L. R. Grigor´eva, A. V. Nemtarev, O. V. Tsepaeva, V. F. Mironov, I. S. Antipin, “Synthesis of C-29-phosphonium derivatives of 3,28-diacetoxylup-20(29)-en-30-oic acid”, Russ Chem Bull, 69:3 (2020), 487
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