O. A. Zhupikova, O. I. Yarovaya, M. K. Marenina, Yu. V. Meshkova, S. V. Belenkaya, D. N. Shcherbakov, A. V. Zaykovskaya, O. V. Pyankov, V. V. Zarubaev, M. G. Mikhalsky, A. Yu. Fedorov, S. G. Arkhipov, V. I. Potkin, I. A. Kolesnik, A. V. Ivanov, N. F. Salakhutdinov, M. V. Khvostov, “New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses”, Mendeleev Commun., 35:2 (2025), 145

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Mendeleev Communications, 2025, Volume 35, Issue 2, Pages 145–147
DOI: https://doi.org/10.71267/mencom.7578 (Mi mendc1357)

Communications

New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses

O. A. Zhupikova^a, O. I. Yarovaya^a, M. K. Marenina^a, Yu. V. Meshkova^a, S. V. Belenkaya^ab, D. N. Shcherbakov^ab, A. V. Zaykovskaya^b, O. V. Pyankov^b, V. V. Zarubaev^c, M. G. Mikhalsky^c, A. Yu. Fedorov^d, S. G. Arkhipov^d, V. I. Potkin^e, I. A. Kolesnik^e, A. V. Ivanov^f, N. F. Salakhutdinov^a, M. V. Khvostov^a

^a N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation
^b State Research Center of Virology and Biotechnology ‘Vector’, 630559 Koltsovo, Novosibirsk Region, Russian Federation
^c St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russian Federationy
^d Institute of Chemical Technology, Novosibirsk State University, 630090 Novosibirsk, Russian Federation
^e Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus
^f A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation

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DOI: https://doi.org/10.71267/mencom.7578

Graphic abstract: New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses

Abstract: New thiosemicarbazones based on 5-arylisoxazole-3-carbaldehyde and substituted pyrrolecarbaldehydes have been obtained. The test for ability to inhibit the main viral protease 3Clpro of SARS-CoV-2 virus revealed a compound with activity against both corona- and influenza viruses.

Keywords: thiosemicarbazones, isoxazoles, tetrahydroindoles, antiviral activity, protease 3Clpro, SARS-CoV-2 virus, influenza A (H1N1) virus, biological activity.

Funding agency	Grant number
Ministry of Science and Higher Education of the Russian Federation	FWUE-2022- 0014 075-15-2021-1355 GZ-43/21

Received: 25.07.2024
Accepted: 03.10.2024

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(697.1 Kb)

Citation: O. A. Zhupikova, O. I. Yarovaya, M. K. Marenina, Yu. V. Meshkova, S. V. Belenkaya, D. N. Shcherbakov, A. V. Zaykovskaya, O. V. Pyankov, V. V. Zarubaev, M. G. Mikhalsky, A. Yu. Fedorov, S. G. Arkhipov, V. I. Potkin, I. A. Kolesnik, A. V. Ivanov, N. F. Salakhutdinov, M. V. Khvostov, “New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses”, Mendeleev Commun., 35:2 (2025), 145–147

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Citing articles in Google Scholar: Russian citations, English citations
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