Abstract:
Novel 4-amino-5-cyano-2-sulfonylpyrimidines were prepared based on three-component cyclization between isothiouronium salts, benzaldehydes and malononitrile, followed by oxidation of the sulfide moiety with Oxone. The cytotoxic activity of the synthesized compounds, as well as the induction of apoptosis, inhibition of the cell cycle and proliferation tests were performed on selected cancer cell lines A431, A549, A375, HCT 116, MCF7, LNCap and SH-SY5Y.
Citation:
D. A. Khochenkov, Yu. A. Khochenkova, Yu. S. Machkova, R. E. Gasanov, E. V. Stepanova, A. S. Bunev, “Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines”, Mendeleev Commun., 30:5 (2020), 604–606
Linking options:
https://www.mathnet.ru/eng/mendc1266
https://www.mathnet.ru/eng/mendc/v30/i5/p604
This publication is cited in the following 2 articles:
Zhaobing Ding, Yizhou Wu, Liu Liu, Bing Qi, Zuozhong Peng, “Construction of Isocytosine Scaffolds via DNA-Compatible Biginelli-like Reaction”, Org. Lett., 25:29 (2023), 5515
Alexander S. Bunev, Dmitry A. Khochenkov, Yulia A. Khochenkova, Yulia S. Machkova, Elena V. Varakina, Rovshan E. Gasanov, Marina A. Troshina, Olga S. Avdyakova, “Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines”, Synthetic Communications, 51:16 (2021), 2521
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