M. I. Lavrov, O. V. Stroganov, V. L. Zamoyski, V. V. Grigoriev, M. E. Zapolskiy, S. V. Sysolyatin, V. V. Malykhin, V. N. Surmachev, V. A. Palyulin, “Synthesis of an allosteric modulator of ionotropic glutamate receptors”, Mendeleev Commun., 30:2 (2020), 156

Mendeleev Communications

RUS ENG

JOURNALS PEOPLE ORGANISATIONS CONFERENCES SEMINARS VIDEO LIBRARY PACKAGE AMSBIB

JavaScript is disabled in your browser. Please switch it on to enable full functionality of the website

	General information
	Latest issue
	Archive

	Search papers
	Search references

	RSS
	Latest issue
	Current issues
	Archive issues
	What is RSS

Mendeleev Commun.:
Year:
Volume:
Issue:
Page:
	Find

Personal entry:
Login:
Password:
	Save password
	Enter
	Forgotten password?
	Register

Mendeleev Communications, 2020, Volume 30, Issue 2, Pages 156–158
DOI: https://doi.org/10.1016/j.mencom.2020.03.008 (Mi mendc1132)

This article is cited in 7 scientific papers (total in 7 papers)

Communications

Synthesis of an allosteric modulator of ionotropic glutamate receptors

M. I. Lavrov^ab, O. V. Stroganov^cd, V. L. Zamoyski^b, V. V. Grigoriev^ab, M. E. Zapolskiy^d, S. V. Sysolyatin^e, V. V. Malykhin^e, V. N. Surmachev^e, V. A. Palyulin^ab

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^d QM Pharma LLC, Skolkovo Innovation Center, Moscow, Russian Federation
^e Institute for Problems of Chemical & Energetic Technologies, Siberian Branch of the Russian Academy of Sciences, Biysk, Russian Federation

Full-text PDF (370 kB) Citations (7)

DOI: https://doi.org/10.1016/j.mencom.2020.03.008

Graphic abstract: Synthesis of an allosteric modulator of ionotropic glutamate receptors

Abstract: Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range of concentrations from 10⁻¹¹ to 10⁻⁶m.

Keywords: 3,7-diazabicyclo[3.3.1]nonane, AMPA receptor, negative allosteric modulator, NAM, patch clamp.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(538.2 Kb)

Citation: M. I. Lavrov, O. V. Stroganov, V. L. Zamoyski, V. V. Grigoriev, M. E. Zapolskiy, S. V. Sysolyatin, V. V. Malykhin, V. N. Surmachev, V. A. Palyulin, “Synthesis of an allosteric modulator of ionotropic glutamate receptors”, Mendeleev Commun., 30:2 (2020), 156–158

Linking options:

https://www.mathnet.ru/eng/mendc1132

https://www.mathnet.ru/eng/mendc/v30/i2/p156

This publication is cited in the following 7 articles:

Aleksei V. Medved'ko, Savelii V. Gaisen, Mikhail A. Kalinin, Sergey Z. Vatsadze, “Bispidine-Based Macrocycles: Achievements and Perspectives”, Organics, 4:3 (2023), 417
Elena A. Golubeva, Mstislav I. Lavrov, Polina N. Veremeeva, Tatiana V. Vyunova, Konstantin V. Shevchenko, Maxim A. Topchiy, Andrey F. Asachenko, Vladimir A. Palyulin, “New Allosteric Modulators of AMPA Receptors: Synthesis and Study of Their Functional Activity by Radioligand-Receptor Binding Analysis”, IJMS, 24:12 (2023), 10293
E. A. Golubeva, M. I. Lavrov, P. N. Veremeeva, E. M. Bovina, E. V. Radchenko, M. A. Topchiy, A. F. Asachenko, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system”, Mendeleev Commun., 33:1 (2023), 70–72
Elena A. Golubeva, Mstislav I. Lavrov, Eugene V. Radchenko, Vladimir A. Palyulin, “Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects”, Biomolecules, 13:1 (2022), 56
M. I. Lavrov, P. N. Veremeeva, E. A. Golubeva, E. V. Radchenko, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “Positive and negative AMPA receptor modulators based on tricyclic bispidine derivative: Minor structural change inverts the type of activity”, Mendeleev Commun., 32:3 (2022), 360–363
E.V. Radchenko, A.S. Tarakanova, D.S. Karlov, M.I. Lavrov, V.A. Palyulin, “Ligands of the AMPA-subtype glutamate receptors: mechanisms of action and novel chemotypes”, BIOMED KHIM, 67:3 (2021), 187
I. Yu. Titov, V. S. Stroylov, P. V. Rusina, I. Svitanko, “Preliminary modelling as the first stage of targeted organic synthesis”, Russian Chem. Reviews, 90:7 (2021), 831–867

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

Statistics & downloads:
Abstract page:	28
Full-text PDF :	8

Registration to the website

Logotypes