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Matematicheskaya Biologiya i Bioinformatika, 2019, Volume 14, Issue 2, Pages 373–392
DOI: https://doi.org/10.17537/2019.14.373 (Mi mbb390) 		 
This article is cited in 6 scientific papers (total in 6 papers)

Mathematical Modeling

A modular visual model of energy metabolism in human skeletal muscle

I. N. Kiselevab, I. R. Akberdinbcd, A. Vertysheve, D. V. Popovf, F. A. Kolpakovab

a Institute of Computational Technologies, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
b BIOSOFT.RU, LLC, Novosibirsk, Russian Federation
c Novosibirsk State University, Novosibirsk, Russian Federation
d Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
e CJSC "Sites-Tsentr", Moscow, Russian Federation
f Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
Full-text PDF (1911 kB) Citations (6)
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DOI: https://doi.org/10.17537/2019.14.373
Abstract: The paper presents a modification of a multi-compartmental mathematical model describing the dynamics of intracellular species concentrations and fluxes in human muscle at rest. A modular representation of a complex model is proposed, which provides the possibility of rapid expansion and modification of the model compartments to account for the complex organization of muscle cells and the limitations of the rate of diffusion of metabolites between intracellular compartments. To illustrate the work of the model, intracellular response in human skeletal muscle to acute aerobic two-legged cycle ergometer training was considered. The model in SBML format is available at http://wiki.biouml.org/index.php/Muscle-metabolism.
Key words: mathematical model, module modeling approach, skeletal muscle, physical exercise, metabolism, physiology, BioUML.
Funding agency Grant number
Russian Foundation for Basic Research 17-00-00308
17-00-00296
Received 23.05.2019, 27.06.2019, Published 11.07.2019
Document Type: Article
UDC: 573.22, 57.032-033
Language: Russian
Citation: I. N. Kiselev, I. R. Akberdin, A. Vertyshev, D. V. Popov, F. A. Kolpakov, “A modular visual model of energy metabolism in human skeletal muscle”, Mat. Biolog. Bioinform., 14:2 (2019), 373–392
Citation in format AMSBIB
\Bibitem{KisAkbVer19}
\by I.~N.~Kiselev, I.~R.~Akberdin, A.~Vertyshev, D.~V.~Popov, F.~A.~Kolpakov
\paper A modular visual model of energy metabolism in human skeletal muscle
\jour Mat. Biolog. Bioinform.
\yr 2019
\vol 14
\issue 2
\pages 373--392
\mathnet{http://mi.mathnet.ru/mbb390}
\crossref{https://doi.org/10.17537/2019.14.373}
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  • https://www.mathnet.ru/eng/mbb390
  • https://www.mathnet.ru/eng/mbb/v14/i2/p373
    • This publication is cited in the following 6 articles:
    1. D. S. Babaev, E. O. Kutumova, F. A. Kolpakov, “Modelirovanie differentsialnogo vliyaniya allelei gena CYP2C9 na metabolizm lozartana”, Matem. biologiya i bioinform., 19:2 (2024), 533–564  mathnet  crossref  elib
    2. Alexander Yu. Vertyshev, Ilya R. Akberdin, Fedor A. Kolpakov, “Numerous Trigger-like Interactions of Kinases/Protein Phosphatases in Human Skeletal Muscles Can Underlie Transient Processes in Activation of Signaling Pathways during Exercise”, IJMS, 24:13 (2023), 11223  crossref
    3. I. R. Akberdin, I. N. Kiselev, S. S. Pintus, R. N. Sharipov, A. Yu. Vertyshev, O. L. Vinogradova, D. V. Popov, F. A. Kolpakov, “A modular mathematical model of exercise-induced changes in metabolism, signaling, and gene expression in human skeletal muscle”, Int. J. Mol. Sci., 22:19 (2021), 10353  crossref  isi
    4. V. A. Likhoshvai, T. M. Khlebodarova, “Evolution and extinction can occur rapidly: a modeling approach”, PeerJ, 9 (2021), e11130  crossref  isi
    5. Chikov A.E., Medvedev D.S., Chikova S.N., Kolmogorov V S., “Features of Energy Supply of Muscle Work Depending on the Duration of Stepwise Increasing Load in Cyclical Sports Athletes”, Hum. Sport Med., 20:4 (2020), 62–68  crossref  isi
    6. I. R. Akberdin, A. Yu. Vertyshev, S. S. Pintus, D. V. Popov, F. A. Kolpakov, “A mathematical model linking Ca2+-dependent signaling pathway and gene expression regulation in human skeletal muscle”, Mat. Biolog. Bioinform., 15:1 (2020), 20–39  mathnet  mathnet  crossref
    Citing articles in Google Scholar: Russian citations, English citations
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